Merkur'eva R V
J Hyg Epidemiol Microbiol Immunol. 1986;30(1):63-9.
Generalizations derived from experimental studies of enzymic disorganization and stability of membranes of cellular structures (microsomes, mitochondria, lysosomes, cytoplasmic membrane) of various organs and systems (liver, kidney, lung, brain, placenta, gonads, alveolar macrophages and others) due to hepato-, neuro-, gonado-, embryotoxic, mutagenic and carcinogenic effect of chemical pollutants of the environment are presented. Evaluation of the membrane-damaging effect taking into account the stage of labilization of biomembranes (according to severity of manifestation) and compensatory defence reactions at the moleculo-cellular level (alveolar macrophages) is recommended. Classification of biochemical methods (according to priority) is proposed for the evaluation of early functional changes during the examination of the health state of the population in dependence on the effect of environmental factors.
介绍了从对各种器官和系统（肝脏、肾脏、肺、脑、胎盘、性腺、肺泡巨噬细胞等）的细胞结构（微粒体、线粒体、溶酶体、细胞质膜）的酶紊乱和膜稳定性进行实验研究中得出的一般结论，这些研究涉及环境化学污染物的肝毒性、神经毒性、性腺毒性、胚胎毒性、诱变和致癌作用。建议在考虑生物膜不稳定阶段（根据表现的严重程度）以及分子细胞水平（肺泡巨噬细胞）的代偿防御反应的情况下，评估膜损伤效应。针对根据环境因素影响来检查人群健康状况时评估早期功能变化，提出了生化方法的分类（按优先级）。
