Leese T, West K P, Morton D B, Bell P R
Department of Surgery, University of Leicester, Leicester Royal Infirmary, U.K.
Int J Pancreatol. 1988 Dec;3(6):437-47. doi: 10.1007/BF02788202.
Fresh frozen plasma therapy was assessed in a rat model of acute haemorrhagic pancreatitis incorporating the facility for continuous intravenous infusion in the unrestrained animal. Infusions including fresh frozen plasma were shown to significantly improve 72 h survival in the model compared to crystalloid (P less than 0.001) and colloid (P less than 0.05) control groups. The mechanism of this improved survival has yet to be elucidated, but this work supports the establishment of a controlled clinical trial of fresh frozen plasma therapy in this disease.
在一个急性出血性胰腺炎大鼠模型中评估了新鲜冰冻血浆疗法，该模型具备在不受限制的动物身上进行连续静脉输注的条件。与晶体液（P<0.001）和胶体液（P<0.05）对照组相比，包括新鲜冰冻血浆在内的输注显示可显著提高该模型中的72小时生存率。这种生存率提高的机制尚未阐明，但这项工作支持针对该疾病开展新鲜冰冻血浆疗法的对照临床试验。
