Ahmed Sundus, Capric Violeta, Khan Muhammad, Koneru Prabash
Internal Medicine, Kings County Hospital Center, Brooklyn, USA.
Internal Medicine, State University of New York Downstate Medical Center, Brooklyn, USA.
Cureus. 2020 Feb 17;12(2):e7021. doi: 10.7759/cureus.7021.
Statins are one of the most commonly used medications to lower cholesterol and have been known to cause various side effects including myalgias, myopathies, and rhabdomyolysis. Statin-induced necrotizing autoimmune myopathy (SINAM), a subtype of inflammatory myopathy, is an exceedingly rare but severe side effect of statin use that manifests as progressive muscle weakness. We describe a rapidly progressive case of SINAM in a 66-year-old Haitian female who developed debilitating symptoms after one month of statin use. Despite aggressive treatment with steroids and immunosuppressants, she failed to regain muscle strength and functional status, and remains on therapy. Given the widespread use of statins, it is important for clinicians to be aware of this condition and its presenting symptoms in order to initiate prompt treatment.
他汀类药物是最常用的降低胆固醇的药物之一，已知会引起各种副作用，包括肌痛、肌病和横纹肌溶解。他汀类药物诱导的坏死性自身免疫性肌病（SINAM）是炎症性肌病的一种亚型，是他汀类药物使用极为罕见但严重的副作用，表现为进行性肌肉无力。我们描述了一名66岁海地女性快速进展的SINAM病例，该患者在使用他汀类药物一个月后出现了使人衰弱的症状。尽管积极使用类固醇和免疫抑制剂进行治疗，但她未能恢复肌肉力量和功能状态，仍在接受治疗。鉴于他汀类药物的广泛使用，临床医生了解这种疾病及其表现症状以便及时开始治疗很重要。
