Bhoompally Hemalatha, Ulavala Praneeth, Vadher Abhishek, Kalangi Hari Chandana, Baraiya Swati
Intensive Care, Yashoda Hospitals, Secunderabad, IND.
General Internal Medicine, Narayana Medical College and Hospital, Nellore, IND.
Cureus. 2024 Sep 19;16(9):e69751. doi: 10.7759/cureus.69751. eCollection 2024 Sep.
Statins are widely prescribed to patients for their efficiency in cholesterol management. However, they carry the risk of inducing a relatively rare, serious, and potentially life-threatening condition known as statin-induced necrotizing autoimmune myopathy (SINAM). This case report provides an in-depth analysis of SINAM, focusing on its epidemiology, clinical presentation, and the challenges involved in accurate diagnosis. In addition, we review evolving theories addressing its pathogenesis and current therapeutic approaches. This report identifies the need for early diagnosis and intervention and recommends a multidisciplinary approach to optimize patient outcomes. This article also highlights the need for further research studies to enhance our understanding of SINAM and its management.
他汀类药物因其在胆固醇管理方面的有效性而被广泛开给患者。然而，它们存在引发一种相对罕见、严重且可能危及生命的疾病的风险，这种疾病被称为他汀类药物诱导的坏死性自身免疫性肌病（SINAM）。本病例报告对SINAM进行了深入分析，重点关注其流行病学、临床表现以及准确诊断所涉及的挑战。此外，我们回顾了关于其发病机制的不断发展的理论和当前的治疗方法。本报告确定了早期诊断和干预的必要性，并推荐采用多学科方法来优化患者的治疗结果。本文还强调了进一步开展研究以加深我们对SINAM及其管理的理解的必要性。
