Tao Yaoye, Wang Jianguo, Xu Xiao
Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
National Health Commission (NHC) Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, China.
Front Bioeng Biotechnol. 2020 Mar 10;8:184. doi: 10.3389/fbioe.2020.00184. eCollection 2020.
Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal solid cancers globally. To improve diagnosis sensitivities and treatment efficacies, the development of new theranostic nanoplatforms for efficient HCC management is urgently needed. In the past decade, mesoporous silica nanoparticles (MSNs) with tailored structure, large surface area, high agents loading volume, abundant chemistry functionality, acceptable biocompatibility have received more and more attention in HCC theranostic. This review outlines the recent advances in MSNs-based systems for HCC therapy and diagnosis. The multifunctional hybrid nanostructures that have both of therapy and diagnosis abilities are highlighted. And the precision delivery strategies of MSNs in HCC are also discussed. Final, we conclude with our personal perspectives on the future development and challenges of MSNs.
肝细胞癌（HCC）是全球最常见且致命的实体癌之一。为提高诊断敏感性和治疗效果，迫切需要开发用于高效管理HCC的新型诊疗纳米平台。在过去十年中，具有定制结构、大表面积、高药物负载量、丰富化学功能且生物相容性良好的介孔二氧化硅纳米颗粒（MSNs）在HCC诊疗中受到越来越多的关注。本文综述了基于MSNs的HCC治疗和诊断系统的最新进展。重点介绍了兼具治疗和诊断能力的多功能杂化纳米结构。还讨论了MSNs在HCC中的精准递送策略。最后，我们就MSNs的未来发展和挑战给出了个人观点。
