Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China .
Adv Mater. 2012 Mar 22;24(12):1504-34. doi: 10.1002/adma.201104763. Epub 2012 Feb 29.
In the past decade, mesoporous silica nanoparticles (MSNs) have attracted more and more attention for their potential biomedical applications. With their tailored mesoporous structure and high surface area, MSNs as drug delivery systems (DDSs) show significant advantages over traditional drug nanocarriers. In this review, we overview the recent progress in the synthesis of MSNs for drug delivery applications. First, we provide an overview of synthesis strategies for fabricating ordered MSNs and hollow/rattle-type MSNs. Then, the in vitro and in vivo biocompatibility and biotranslocation of MSNs are discussed in relation to their chemophysical properties including particle size, surface properties, shape, and structure. The review also highlights the significant achievements in drug delivery using mesoporous silica nanoparticles and their multifunctional counterparts as drug carriers. In particular, the biological barriers for nano-based targeted cancer therapy and MSN-based targeting strategies are discussed. We conclude with our personal perspectives on the directions in which future work in this field might be focused.
在过去的十年中，介孔硅纳米粒子（MSNs）因其在生物医学中的潜在应用而受到越来越多的关注。MSNs 具有可调节的介孔结构和高表面积，作为药物传递系统（DDS），相比于传统药物纳米载体具有显著的优势。在这篇综述中，我们概述了用于药物传递应用的 MSNs 的合成的最新进展。首先，我们提供了用于制造有序 MSNs 和中空/响铃型 MSNs 的合成策略概述。然后，我们讨论了 MSNs 的体外和体内生物相容性和生物迁移与其化学物理性质（包括粒径、表面性质、形状和结构）之间的关系。该综述还强调了在药物传递中使用介孔硅纳米粒子及其多功能对应物作为药物载体的重要进展。特别地，讨论了基于纳米的靶向癌症治疗和基于 MSN 的靶向策略的生物屏障。我们最后总结了我们对该领域未来工作重点的个人看法。
