马吲哚对杜氏肌营养不良症男孩生长激素分泌的影响。
The effect of mazindol on growth hormone secretion in boys with Duchenne muscular dystrophy.
作者信息
Coakley J H, Moorcraft J, Hipkin L J, Smith C S, Griffiths R D, Edwards R H
机构信息
University Department of Medicine, Royal Liverpool Hospital, UK.
出版信息
J Neurol Neurosurg Psychiatry. 1988 Dec;51(12):1551-7. doi: 10.1136/jnnp.51.12.1551.
Abstract
Mazindol has been reported to improve muscle function in Duchenne muscular dystrophy (DMD) by virtue of its growth hormone (GH) suppression. The effects were studied on GH secretion (in response to growth hormone releasing factor and sleep) of mazindol 2 mg daily for 3 months in five boys with DMD. No consistent change was found following mazindol therapy. Adverse effects were noted in all the boys which may preclude long term use of mazindol in DMD.
摘要
据报道，马吲哚因其对生长激素（GH）的抑制作用而改善杜氏肌营养不良症（DMD）患者的肌肉功能。对五名DMD男孩进行了研究，他们每天服用2毫克马吲哚，持续3个月，观察其对GH分泌的影响（对生长激素释放因子和睡眠的反应）。马吲哚治疗后未发现一致的变化。所有男孩均出现不良反应，这可能使马吲哚无法长期用于DMD患者。
相似文献
1
The effect of mazindol on growth hormone secretion in boys with Duchenne muscular dystrophy.马吲哚对杜氏肌营养不良症男孩生长激素分泌的影响。
J Neurol Neurosurg Psychiatry. 1988 Dec;51(12):1551-7. doi: 10.1136/jnnp.51.12.1551.
2
Effect of mazindol on growth hormone levels in patients with Duchenne muscular dystrophy.马吲哚对杜氏肌营养不良症患者生长激素水平的影响。
Am J Med Genet. 1988 Dec;31(4):821-33. doi: 10.1002/ajmg.1320310415.
3
Nocturnal rhythm of growth hormone in Duchenne patients: effect of different doses of mazindol and/or cyproheptadine.杜兴氏患者生长激素的夜间节律：不同剂量马吲哚和/或赛庚啶的影响。
Am J Med Genet. 1989 Aug;33(4):457-67. doi: 10.1002/ajmg.1320330408.
4
Mazindol and growth hormone inhibition in Duchenne muscular dystrophy.马吲哚与杜氏肌营养不良症中的生长激素抑制
Am J Med Genet. 1987 Aug;27(4):993-5. doi: 10.1002/ajmg.1320270433.
5
Treatment of Duchenne muscular dystrophy with growth hormone inhibitors.使用生长激素抑制剂治疗杜氏肌营养不良症。
Am J Med Genet. 1986 Jul;24(3):549-66. doi: 10.1002/ajmg.1320240322.
6
Mazindol in Duchenne muscular dystrophy.马吲哚治疗杜氏肌营养不良症
Lancet. 1988 Jan 23;1(8578):184. doi: 10.1016/s0140-6736(88)92759-6.
7
Growth hormone inhibition causes increased selenium levels in Duchenne muscular dystrophy: a possible new approach to therapy.生长激素抑制导致杜氏肌营养不良症患者硒水平升高：一种可能的新治疗方法。
J Med Genet. 1984 Aug;21(4):254-6. doi: 10.1136/jmg.21.4.254.
8
Randomized, double-blind trial of mazindol in Duchenne dystrophy.
Muscle Nerve. 1990 Dec;13(12):1169-73. doi: 10.1002/mus.880131212.
9
10
[Effect of a growth hormone inhibitor on the course of Duchenne's myopathy].[生长激素抑制剂对杜氏肌病病程的影响]
Presse Med. 1988 Nov 19;17(41):2201.
引用本文的文献
1
Drug repositioning or target repositioning: A structural perspective of drug-target-indication relationship for available repurposed drugs.药物重新定位或靶点重新定位：现有重新利用药物的药物-靶点-适应症关系的结构视角
Comput Struct Biotechnol J. 2020 Apr 13;18:1043-1055. doi: 10.1016/j.csbj.2020.04.004. eCollection 2020.
2
Obesity and Endocrine Management of the Patient With Duchenne Muscular Dystrophy.肥胖与杜氏肌营养不良症患者的内分泌管理。
Pediatrics. 2018 Oct;142(Suppl 2):S43-S52. doi: 10.1542/peds.2018-0333F.
3
Medication Repurposing in Pediatric Patients: Teaching Old Drugs New Tricks.儿科患者中的药物重新利用：让老药发挥新作用
J Pediatr Pharmacol Ther. 2016 Jan-Feb;21(1):36-53. doi: 10.5863/1551-6776-21.1.36.
4
Psychiatric disorders in Prader-Willi syndrome: epidemiology and management.普拉德-威利综合征中的精神障碍：流行病学与管理
CNS Drugs. 2003;17(3):167-78. doi: 10.2165/00023210-200317030-00003.
本文引用的文献
1
Unexpected differences between mazindol and its homologs on biochemical and behavioral responses.
J Pharmacol Exp Ther. 1981 Jun;217(3):745-9.
2
Sleep-induced growth hormone release--evaluation of a simple test for clinical use.睡眠诱导生长激素释放——一种用于临床的简易测试的评估
Arch Dis Child. 1983 Mar;58(3):220-2. doi: 10.1136/adc.58.3.220.
3
Weight reduction in boys with muscular dystrophy.患有肌肉萎缩症男孩的体重减轻
Dev Med Child Neurol. 1984 Jun;26(3):384-90. doi: 10.1111/j.1469-8749.1984.tb04457.x.
4
Growth hormone inhibition causes increased selenium levels in Duchenne muscular dystrophy: a possible new approach to therapy.生长激素抑制导致杜氏肌营养不良症患者硒水平升高：一种可能的新治疗方法。
J Med Genet. 1984 Aug;21(4):254-6. doi: 10.1136/jmg.21.4.254.
5
Techniques for studying free radical damage in muscular dystrophy.
Med Biol. 1984;62(2):135-8.
6
Potential uses of human pancreatic growth hormone-releasing factor 1-44 amide.
Clin Endocrinol (Oxf). 1984 Aug;21(2):201-8. doi: 10.1111/j.1365-2265.1984.tb03460.x.
7
Acute effects of mazindol on the secretion of ACTH, beta-lipotropin, beta-endorphin and cortisol in man.马吲哚对人体促肾上腺皮质激素、β-促脂素、β-内啡肽和皮质醇分泌的急性影响。
Endocrinol Jpn. 1984 Oct;31(5):523-8. doi: 10.1507/endocrj1954.31.523.
8
Human growth hormone and estrogens in boys with Duchenne muscular dystrophy.杜氏肌营养不良症男孩体内的人生长激素和雌激素
Arch Phys Med Rehabil. 1973 Jun;54(6):248-53.
9
Selenium supplementation in X-linked muscular dystrophy. Effects on erythrocyte and serum selenium and on erythrocyte glutathione peroxidase activity.
Acta Paediatr Scand. 1985 Nov;74(6):886-90. doi: 10.1111/j.1651-2227.1985.tb10053.x.
10
Fenfluramine and mazindol: acute reversible cardiomyopathy associated with their use.芬氟拉明和马吲哚：与其使用相关的急性可逆性心肌病。
Int J Psychiatry Med. 1985;15(2):197-200. doi: 10.2190/yq38-eag3-319r-a8rl.
Zotero 插件