Edwards R H, Round J M, Jackson M J, Griffiths R D, Lilburn M F
Dev Med Child Neurol. 1984 Jun;26(3):384-90. doi: 10.1111/j.1469-8749.1984.tb04457.x.
Many children with muscular dystrophy are overweight, and although weight control is pursued in some centres it is unusual to encourage severe dietary restriction for fear that it might lead to accelerated loss of muscle. In this study, two overweight boys with muscular dystrophy were monitored by whole-body nitrogen balance, total body potassium, strength and functional measurements during calorie restriction. Both patients were found to have a transient loss of nitrogen on commencing the low calorie intake: thereafter, weight loss was not found to have any deleterious effect on muscle bulk or function in either patient. It is suggested that controlled weight-reduction in obese children with muscular dystrophy is a safe and practical way of losing excess fat, which can improve mobility and self-esteem, and may possibly effect longevity.
许多患有肌肉萎缩症的儿童超重，尽管一些治疗中心会进行体重控制，但通常不会鼓励严格的饮食限制，因为担心这可能会导致肌肉加速流失。在这项研究中，两名患有肌肉萎缩症的超重男孩在热量限制期间通过全身氮平衡、全身钾含量、力量和功能测量进行监测。两名患者在开始低热量摄入时均出现短暂的氮流失：此后，未发现体重减轻对任何一名患者的肌肉量或功能有任何有害影响。研究表明，对患有肌肉萎缩症的肥胖儿童进行有控制的体重减轻是一种安全可行的减少多余脂肪的方法，这可以改善活动能力和自尊心，并且可能对寿命产生影响。
