生长激素抑制导致杜氏肌营养不良症患者硒水平升高：一种可能的新治疗方法。
Growth hormone inhibition causes increased selenium levels in Duchenne muscular dystrophy: a possible new approach to therapy.
作者信息
Collipp P J, Kelemen J, Chen S Y, Castro-Magana M, Angulo M, Derenoncourt A
出版信息
J Med Genet. 1984 Aug;21(4):254-6. doi: 10.1136/jmg.21.4.254.
Nine children with Duchenne muscular dystrophy were given Sanorex (mazindol), a growth hormone inhibitor, daily for 6 months. There was no significant change in their muscle function, but there was a significant reduction in weight gain and in levels of growth hormone, somatomedin C, hair zinc, serum zinc, and serum LDH. Selenium and glutathione peroxidase in the serum increased significantly. Thirteen other children with growth hormone deficiency had a significant reduction in hair selenium following growth hormone administration. These results show a significant relationship between growth hormone and selenium nutritional status and confirm our previous reports indicating an effect of growth hormone on zinc nutritional status. It is possible that prolonged therapy with a growth hormone inhibitor would attenuate the course and improve the longevity of patients with muscular dystrophy.
九名患有杜氏肌营养不良症的儿童每天服用生长激素抑制剂Sanorex（马吲哚），持续6个月。他们的肌肉功能没有显著变化，但体重增加、生长激素、胰岛素样生长因子C、头发锌、血清锌和血清乳酸脱氢酶水平均显著降低。血清中的硒和谷胱甘肽过氧化物酶显著增加。另外十三名生长激素缺乏的儿童在接受生长激素治疗后，头发硒含量显著降低。这些结果表明生长激素与硒营养状况之间存在显著关系，并证实了我们之前的报告，即生长激素对锌营养状况有影响。使用生长激素抑制剂进行长期治疗有可能减缓肌营养不良症患者的病程并延长其寿命。
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