Reef V B, Levitan C W, Spencer P A
Department of Clinical Studies, University of Pennsylvania, Kennett Square 19348.
J Vet Intern Med. 1988 Jan-Mar;2(1):1-6. doi: 10.1111/j.1939-1676.1988.tb01970.x.
Sixty-seven horses presented with atrial fibrillation (AF) from January 1, 1980 to August 1, 1986. All horses were evaluated for the type and severity of the underlying cardiac disease and the probable duration of the arrhythmia. Fifty-two (78%) of the horses were treated with quinidine sulfate and/or digoxin. The response to treatment was assessed in each horse. Horses were followed for periods extending from 8 months to 7 years. Standardbreds, young horses, and males predominated in the study group. There were more male horses (stallions and geldings) than mares. Most horses with AF had no evidence of other cardiac disease (56.7%). All performance horses without other cardiac disease were treated, and return to performance was significantly associated with conversion to sinus rhythm. Horses that did not convert with quinidine sulfate therapy, whose arrhythmia recurred, and that had side effects from quinidine sulfate therapy, had a longer history of poor performance. Tachycardia (heart rate greater than 60 beats/min) was significantly associated with the existence of congestive heart failure. The horses with congestive heart failure had a poor prognosis for life (7.7% survived) and a poor conversion to normal sinus rhythm (23.1%). Mitral regurgitation (19 horses) was the most common underlying cardiac disease. Tricuspid regurgitation (15 horses), aortic regurgitation (3 horses), myocardial dysfunction (3 horses), and atrial septal defect (1 horse) also were diagnosed. Congestive heart failure was common in this group of horses with underlying cardiac disease.
1980年1月1日至1986年8月1日期间，67匹马出现心房颤动（AF）。对所有马匹的潜在心脏疾病类型和严重程度以及心律失常的可能持续时间进行了评估。其中52匹（78%）马接受了硫酸奎尼丁和/或地高辛治疗。评估了每匹马对治疗的反应。对马匹进行了8个月至7年的随访。研究组中标准赛马、年轻马匹和雄性马匹占主导。雄性马（种马和去势公马）比母马多。大多数患有房颤的马没有其他心脏病的证据（56.7%）。所有无其他心脏病的参赛马都接受了治疗，恢复参赛与转为窦性心律显著相关。未通过硫酸奎尼丁治疗转为窦性心律、心律失常复发且出现硫酸奎尼丁治疗副作用的马，其表现不佳的病史更长。心动过速（心率大于60次/分钟）与充血性心力衰竭的存在显著相关。患有充血性心力衰竭的马生存预后较差（7.7%存活），转为正常窦性心律的情况也较差（23.1%）。二尖瓣反流（19匹马）是最常见的潜在心脏疾病。还诊断出三尖瓣反流（15匹马）、主动脉反流（3匹马）、心肌功能障碍（3匹马）和房间隔缺损（1匹马）。充血性心力衰竭在这群患有潜在心脏疾病的马中很常见。
