Mauldin G N, Matus R E, Patnaik A K, Bond B R, Mooney S C
Donaldson-Atwood Cancer Clinic, Animal Medical Center, New York, NY 10021.
J Vet Intern Med. 1988 Apr-Jun;2(2):60-5. doi: 10.1111/j.1939-1676.1988.tb02794.x.
Twenty-three cats with malignant, nonhematopoietic tumors were treated with doxorubicin and cyclophosphamide. Fourteen cats had nonresectable tumors of the mammary gland, and nine had tumors of the oral cavity. Of the cats with mammary gland adenocarcinoma, seven cats had a partial response to treatment and seven cats had no response. Of the cats with oral tumors, one cat had a complete response, three cats had a partial response, and five cats had no response. All 23 cats are dead because of tumor progression or recurrence. Toxic effects were seen in 18 of the cats; most were transient and required no alteration in the treatment protocol. A high response rate combined with acceptable toxicity warrants further evaluation of combination doxorubicin and cyclophosphamide chemotherapy in cats with nonhematopoietic neoplasia.
23只患有恶性非造血系统肿瘤的猫接受了阿霉素和环磷酰胺治疗。14只猫患有无法切除的乳腺肿瘤，9只患有口腔肿瘤。在患有乳腺腺癌的猫中，7只对治疗有部分反应，7只无反应。在患有口腔肿瘤的猫中，1只完全缓解，3只部分缓解，5只无反应。所有23只猫均因肿瘤进展或复发死亡。18只猫出现了毒性作用；大多数是短暂的，无需改变治疗方案。高缓解率与可接受的毒性表明，对于患有非造血系统肿瘤的猫，阿霉素和环磷酰胺联合化疗值得进一步评估。
