环磷酰胺解救治疗猫在用苯丁酸氮芥治疗复发性低级别胃肠道淋巴瘤。
Cyclophosphamide rescue therapy for relapsed low-grade alimentary lymphoma after chlorambucil treatment in cats.
机构信息
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Denney Veterinary Services, Vicksburg, MI, USA.
出版信息
J Feline Med Surg. 2021 Oct;23(10):976-986. doi: 10.1177/1098612X21996498. Epub 2021 Mar 1.
OBJECTIVES
The aims of this study were to evaluate the response, outcome and prognostic factors in cats with clinically presumed relapsed low-grade alimentary lymphoma (LGAL) receiving cyclophosphamide as a first-line rescue therapy after failing chlorambucil treatment.
METHODS
The medical records of 20 cats (from three institutions, between 2002 and 2017) treated with cyclophosphamide for relapsed LGAL after initial treatment with chlorambucil were retrospectively reviewed. Progression-free survival (PFS), overall survival time (OST) and the association of select variables with measures of outcome were assessed. Adverse events (AEs) were also described.
RESULTS
Eighteen cats (90%) achieved a complete clinical response (CR) for a median duration of 239 days. The median PFS was 215 days. The median OST was 1065 days. The only clinical factor associated with a longer PFS was achievement of a CR with cyclophosphamide treatment. Cyclophosphamide was associated with few and reversible constitutional, gastrointestinal and hematologic AEs.
CONCLUSIONS AND RELEVANCE
Cyclophosphamide appears to be a safe and effective first-rescue therapeutic option for cats with relapsed LGAL.
目的
本研究旨在评估在最初接受苯丁酸氮芥治疗后复发的低级别胃肠道淋巴瘤（LGAL）猫接受环磷酰胺作为一线挽救治疗的反应、结果和预后因素。
方法
回顾性分析了 2017 年至 2002 年间在三家机构接受环磷酰胺治疗的 20 只接受环磷酰胺治疗的复发 LGAL 猫（初始治疗为苯丁酸氮芥）的病历。评估无进展生存期（PFS）、总生存期（OST）和选择变量与预后测量的相关性。还描述了不良事件（AE）。
结果
18 只猫（90%）获得完全临床缓解（CR），中位缓解持续时间为 239 天。中位 PFS 为 215 天。中位 OST 为 1065 天。唯一与更长 PFS 相关的临床因素是环磷酰胺治疗后达到 CR。环磷酰胺与少数且可逆转的全身性、胃肠道和血液学 AE 相关。
结论和相关性
环磷酰胺似乎是复发的低级别胃肠道淋巴瘤猫的一种安全有效的一线挽救治疗选择。
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