Amphibian Research Center, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan.
Graduate School of Integrated Sciences for Life, Amphibian Research Center, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8526, Japan.
Genes (Basel). 2020 Mar 24;11(3):341. doi: 10.3390/genes11030341.
During embryonic development in vertebrates, morphogens play an important role in cell fate determination and morphogenesis. Bone morphogenetic proteins (BMPs) belonging to the transforming growth factor-β (TGF-β) family control the dorsal-ventral (DV) patterning of embryos, whereas other morphogens such as fibroblast growth factor (FGF), Wnt family members, and retinoic acid (RA) regulate the formation of the anterior-posterior (AP) axis. Activation of morphogen signaling results in changes in the expression of target genes including transcription factors that direct cell fate along the body axes. To ensure the correct establishment of the body plan, the processes of DV and AP axis formation must be linked and coordinately regulated by a fine-tuning of morphogen signaling. In this review, we focus on the interplay of various intracellular regulatory mechanisms and discuss how communication among morphogen signaling pathways modulates body axis formation in vertebrate embryos.
在脊椎动物的胚胎发育过程中，形态发生素在细胞命运决定和形态发生中起着重要作用。属于转化生长因子-β（TGF-β）家族的骨形态发生蛋白（BMPs）控制胚胎的背-腹（DV）模式形成，而其他形态发生素，如成纤维细胞生长因子（FGF）、Wnt 家族成员和视黄酸（RA），则调节前后（AP）轴的形成。形态发生素信号的激活导致靶基因表达的变化，包括沿体轴指导细胞命运的转录因子。为了确保正确建立身体计划，DV 和 AP 轴形成的过程必须通过精细调节形态发生素信号进行连接和协调调节。在这篇综述中，我们重点讨论了各种细胞内调节机制的相互作用，并讨论了形态发生素信号通路之间的通讯如何调节脊椎动物胚胎的身体轴形成。
