Gao Hong, Peng Jingpian, Deng Wei, Shi Dazhao, Bao Linlin, Wang Dehua, Zhang Binglin, Qin Chuan, Zhang Zhibin
1Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing, China.
2State Key Laboratory of Integrated Management on Pest Insects and Rodents, State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080 Beijing, China.
Chin Sci Bull. 2005;50(12):1199-1204. doi: 10.1007/BF03183693.
We studied the infectious effect of SARS-CoV virus on juvenile and adult Brandt's Vole (Microtus brandtii) by nasal cavity spraying method (CCID is 10). SARS virus caused serious deaths in adults. The death adults demonstrated hemorrhage from mouth, nasal cavity and intestine, hemorrhageious interstitial pneumonia and gore in liver, spleen and kidney. The survival adults demonstrated local hemorrhagic spot in lung and emphysema, but the other organs showed no pathological abnormality. SARS virus caused no deaths in juveniles, but locomotion of infected juveniles became slower. In the early stage, there was local pneumonia in lung and SARS viruses were isolated from the pathological tissue. Only one control juvenile lived and the infected juvenile showed local pneumonia in lung. The results demonstrated that SARS-CoV infected Brandt's vole seriously and adults were more susceptive to SARS-CoV than juveniles. The Brandt's vole may be a potential animal model for SARS research.
我们通过鼻腔喷雾法（CCID为10）研究了SARS-CoV病毒对幼年和成年布氏田鼠（Microtus brandtii）的感染作用。SARS病毒导致成年布氏田鼠严重死亡。死亡的成年布氏田鼠表现出口腔、鼻腔和肠道出血，出血性间质性肺炎以及肝脏、脾脏和肾脏出现淤血。存活的成年布氏田鼠肺部出现局部出血点和肺气肿，但其他器官未显示出病理异常。SARS病毒未导致幼年布氏田鼠死亡，但感染的幼年布氏田鼠运动变得迟缓。早期，肺部出现局部肺炎，且从病理组织中分离出SARS病毒。仅一只对照幼年布氏田鼠存活，感染的幼年布氏田鼠肺部出现局部肺炎。结果表明，SARS-CoV严重感染布氏田鼠，且成年布氏田鼠比幼年布氏田鼠对SARS-CoV更易感。布氏田鼠可能是SARS研究的潜在动物模型。
