坤泰胶囊与克龄蒙联合治疗卵巢早衰的疗效：一项Meta分析

Effectiveness of Cotreatment with Kuntai Capsule and Climen for Premature Ovarian Failure: A Meta-Analysis.

作者信息

Ma Qianwen, Tan Yong, Mo Genlin

机构信息

Gynecology Department, Zhenjiang Hospital Affiliated to Nanjing University of Chinese Medicine (Zhenjiang Hospital of Traditional Chinese Medicine), Zhenjiang, China.

Reproductive Medicine Department, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

出版信息

Evid Based Complement Alternat Med. 2020 Feb 19;2020:4367359. doi: 10.1155/2020/4367359. eCollection 2020.

OBJECTIVE

To compare the treatment efficacy of Kuntai capsule with Climen only in the therapy of premature ovarian failure.

METHODS

Randomized controlled trials were electronically retrieved from PubMed, Cochrane Library, Web of science, CBM, CNKI, Wanfang, and Weipu database. In addition, some related papers were manually checked. All papers were assessed according to the Cochrane Handbook for Systematic Reviews of Interventions, and the effective data were analyzed by Revman 5.3 Software.

RESULTS

11 randomized control trials involving 1068 patients were included. Results of meta-analysis showed that E (estrogen), the total therapeutic effective rate of the group of Kuntai capsule, and hormone were higher than hormone only. The LH (luteinizing hormone), FSH (follicle-stimulating hormone), and Kupperman score of the group of Kuntai capsule and Climen were lower than Climen only.

CONCLUSION

Available evidence shows that Kuntai capsule with Climen is more effective than Climen in the therapy of premature ovarian failure. Nowadays, the quality of the research studies is low. More large-scaled randomized trials will need to be carried out.

目的

比较坤泰胶囊与单纯使用克龄蒙治疗卵巢早衰的疗效。

方法

通过电子检索PubMed、Cochrane图书馆、Web of science、中国生物医学文献数据库（CBM）、中国知网（CNKI）、万方数据库和维普数据库中的随机对照试验。此外，还手动查阅了一些相关论文。所有论文均按照《Cochrane系统评价干预措施手册》进行评估，并使用Revman 5.3软件对有效数据进行分析。