Grevert P, Goldstein A
Proc Natl Acad Sci U S A. 1977 Mar;74(3):1291-4. doi: 10.1073/pnas.74.3.1291.
The hypothesis that painful stimuli activate the endogenous opioid (endorphin) system in humans was tested by examining the effect of the opiate antagonist naloxone on experimentally induced ischemic pain and on subjective mood ratings. Intravenous injections of saline or naloxone hydrochloride (2 and 10 mg) were administered under double-blind conditions to 12 subjects. Naloxone did not affect the pain ratings. However, a significant dose-related effect of naloxone on tension-anxiety was found, suggesting that the endorphins. like exogenously administered opiates, may have antianxiety properties.
通过研究阿片拮抗剂纳洛酮对实验诱导的缺血性疼痛和主观情绪评分的影响，来检验疼痛刺激激活人类内源性阿片（内啡肽）系统这一假说。在双盲条件下，对12名受试者静脉注射生理盐水或盐酸纳洛酮（2毫克和10毫克）。纳洛酮不影响疼痛评分。然而，发现纳洛酮对紧张焦虑有显著的剂量相关效应，这表明内啡肽可能像外源性给予的阿片类药物一样具有抗焦虑特性。
