Grevert P, Goldstein A
Science. 1978 Mar 10;199(4333):1093-5. doi: 10.1126/science.343250.
In 30 human subjects, experimental pain was produced by either ischemia or cold-water immersion. In a double-blind procedure, intravenous doses of up to 10 milligrams of naloxone hydrochloride in saline were indistinguishable from similarly administered saline alone. There were no effects on subjective pain ratings, finger plethysmograph recordings, or responses to mood-state questionnaires. These laboratory procedures do not activate any functionally significant pain-attenuating or mood-altering effect of endorphins.
在30名人体受试者中，通过局部缺血或冷水浸泡产生实验性疼痛。在双盲程序中，静脉注射高达10毫克盐酸纳洛酮的生理盐水剂量与单独给予的类似生理盐水无法区分。对主观疼痛评分、手指体积描记图记录或情绪状态问卷的反应均无影响。这些实验室程序不会激活内啡肽任何功能上显著的减轻疼痛或改变情绪的作用。
