Department of Chemistry, University of KwaZulu-Natal, King Edward Avenue, Scottsville, Private Bag X01, Pietermaritzburg, 3209, South Africa.
Bull Environ Contam Toxicol. 2020 Apr;104(4):464-470. doi: 10.1007/s00128-020-02829-6. Epub 2020 Mar 25.
This work reports on the method optimization and application for quantitative analysis of non-steroidal anti-inflammatory drugs and anti-epileptic drug in soil and sediment samples. The analytes were extracted by ultrasonic extraction followed by solid phase extraction and quantified using liquid chromatographic coupled with photodiode array. The sensitivity of the method was determined based on the limit of detection and the limit of quantification which ranged between (0.010-0.027 µg/kg) and (0.025-0.049 µg/kg), respectively. The %recoveries of the method ranged between 74% and 112%. The concentrations obtained in real samples ranged from 0.055 to 0.426 µg/kg in sediment and 0.044-0.567 µg/kg in soil samples. The highest concentration was found for diclofenac in soil samples.
本工作报道了一种用于定量分析土壤和沉积物中非甾体抗炎药和抗癫痫药的方法优化和应用。采用超声提取，固相萃取，再结合光电二极管阵列的液相色谱对分析物进行提取和定量。方法的灵敏度基于检出限和定量限来确定，检出限和定量限分别在（0.010-0.027μg/kg）和（0.025-0.049μg/kg）之间。方法的回收率在 74%到 112%之间。在实际样品中获得的浓度范围为 0.055 到 0.426μg/kg 的沉积物和 0.044 到 0.567μg/kg 的土壤样品。在土壤样品中，二氯芬酸的浓度最高。
