Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.
Jpn J Ophthalmol. 2020 Jul;64(4):378-384. doi: 10.1007/s10384-020-00738-z. Epub 2020 Mar 25.
To study the changes in intraocular pressure (IOP) and aqueous flare in eyes with multiple evanescent white dot syndrome (MEWDS) during the disease course.
Retrospective observational study.
Twenty-one patients with unilateral MEWDS were retrospectively evaluated. IOP values were compared between the affected and fellow eyes 2 weeks, 1 month, and 3 months following disease onset in 17 patients, and within 7 days from disease onset in 11 patients. Aqueous flare values measured using a laser flare-cell meter in ten eyes between 1 weeks and 1 month from disease onset were compared between the affected and fellow eyes.
IOP values were significantly lower in the affected eyes than in the fellow eyes at both 2 weeks (P=0.002) and 1 month from disease onset (P=0.02). However, IOP values of affected eyes did not show significant differences from the fellow eyes within 7 days ((P=0.11) and 3 months of onset (P=0.30). Aqueous flare values were significantly increased in the affected eyes compared to those in the fellow eyes (P=0.010) and significantly correlated with IOP values (r=-0.67, P=0.035).
IOP values mildly decreased in association with aqueous flare values in the acute phase in eyes with MEWDS.
研究多发性一过性白点综合征（MEWDS）患者疾病过程中眼内压（IOP）和房水闪辉的变化。
回顾性观察研究。
回顾性评估了 21 例单侧 MEWDS 患者。在 17 例患者中，比较了疾病发病后 2 周、1 个月和 3 个月时患眼和对侧眼的 IOP 值，在 11 例患者中比较了疾病发病后 7 天内的 IOP 值。比较了发病后 1 周到 1 个月的 10 只眼中，激光房水闪辉计测量的房水闪辉值在患眼和对侧眼之间的差异。
与对侧眼相比，患病眼在发病后 2 周（P=0.002）和 1 个月（P=0.02）时的 IOP 值明显较低。然而，在发病后 7 天内（P=0.11）和 3 个月内（P=0.30），患眼的 IOP 值与对侧眼无显著差异。与对侧眼相比，患眼的房水闪辉值明显升高（P=0.010），且与 IOP 值显著相关（r=-0.67，P=0.035）。
在 MEWDS 急性发病期，IOP 值与房水闪辉值呈轻度下降相关。
