Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Department of Ophthalmology, Institute of Vision Research, Severance Eye Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Ocul Immunol Inflamm. 2022 Jan 2;30(1):81-89. doi: 10.1080/09273948.2020.1795206. Epub 2020 Sep 1.
To evaluate multifocal evanescent white dot syndrome (MEWDS) patients with and without overlapping multifocal choroiditis (MFC).
Thirty-four patients diagnosed between November 2008 and August 2018 at 2 hospitals were retrospectively reviewed. Multimodal imaging including optical coherence tomography angiography (OCTA) was assessed.
Twenty-seven (79%) patients were women (overall mean age, 30 years). Five developed MFC lesions in the affected eyes, and one developed MFC in the unaffected fellow eye. Another developed combined MEWDS and MFC in the fellow eye during follow-up. Eyes with MFC had thicker choroids (316.5 and 197.3 µm, respectively; = .001) at presentation, which became thinner after resolution ( = .043). Those with subfoveal MFC had poor visual prognosis ( = .019). Areas of suspected choriocapillaris flow deficit were identified on OCTA.
Some MEWDS patients may develop overlapping MFC in the same or fellow eyes, presenting with increased choroidal thickness which decreased after resolution.
评估伴有和不伴有重叠性多灶性脉络膜炎（MFC）的多灶性隐匿性白点综合征（MEWDS）患者。
回顾性分析了 2008 年 11 月至 2018 年 8 月在 2 家医院诊断的 34 例患者。评估了包括光相干断层扫描血管造影（OCTA）在内的多种模态成像。
27 名（79%）患者为女性（总体平均年龄为 30 岁）。5 只眼在受累眼中出现 MFC 病变，1 只眼在未受累对侧眼中出现 MFC。另有 1 例在随访中出现对侧眼 MEWDS 和 MFC 合并。出现 MFC 的眼在发病时脉络膜较厚（分别为 316.5 和 197.3 µm， =.001），在缓解后变薄（ =.043）。那些有中心凹下 MFC 的眼视力预后较差（ =.019）。OCTA 上可识别疑似脉络膜毛细血管血流不足的区域。
一些 MEWDS 患者可能在同一眼或对侧眼出现重叠性 MFC，表现为脉络膜厚度增加，缓解后变薄。
