Oh Chang Myung, Ryu Dongryeol, Cho Sungsoo, Jang Yangsoo
Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Korea.
Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea.
Korean Circ J. 2020 May;50(5):395-405. doi: 10.4070/kcj.2019.0416.
Despite considerable efforts to prevent and treat cardiovascular disease (CVD), it has become the leading cause of death worldwide. Cardiac mitochondria are crucial cell organelles responsible for creating energy-rich ATP and mitochondrial dysfunction is the root cause for developing heart failure. Therefore, maintenance of mitochondrial quality control (MQC) is an essential process for cardiovascular homeostasis and cardiac health. In this review, we describe the major mechanisms of MQC system, such as mitochondrial unfolded protein response and mitophagy. Moreover, we describe the results of MQC failure in cardiac mitochondria. Furthermore, we discuss the prospects of 2 drug candidates, urolithin A and spermidine, for restoring mitochondrial homeostasis to treat CVD.
尽管在预防和治疗心血管疾病（CVD）方面付出了巨大努力，但它已成为全球主要的死亡原因。心脏线粒体是负责产生富含能量的三磷酸腺苷（ATP）的关键细胞器，而线粒体功能障碍是心力衰竭发展的根本原因。因此，维持线粒体质量控制（MQC）是心血管稳态和心脏健康的重要过程。在本综述中，我们描述了MQC系统的主要机制，如线粒体未折叠蛋白反应和线粒体自噬。此外，我们描述了心脏线粒体中MQC失败的结果。此外，我们还讨论了两种候选药物——尿石素A和亚精胺，用于恢复线粒体稳态以治疗CVD的前景。
