Department of Radiation Oncology & Therapy, Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University , Changchun, China.
NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University , Changchun, China.
Gut Microbes. 2020 Jul 3;11(4):691-705. doi: 10.1080/19490976.2020.1739794. Epub 2020 Mar 27.
Immunotherapy using immune-checkpoint inhibitors is revolutionizing oncotherapy. However, the application of immunotherapy may be restricted because of the lack of proper biomarkers in a portion of cancer patients. Recently, emerging evidence has revealed that gut commensal bacteria can impact the therapeutic efficacy of immune-checkpoint inhibitors in several cancer models. In addition, testing the composition of gut bacteria provides context for prediction of the efficacy and toxicity of immunotherapy. In this review, we discuss the impacts of gut commensal bacteria on the tumoral immune milieu, highlighting some typical bacteria and their associations with immunotherapy.
免疫检查点抑制剂的免疫疗法正在彻底改变肿瘤治疗。然而，由于一部分癌症患者缺乏适当的生物标志物，免疫疗法的应用可能受到限制。最近，新出现的证据表明，肠道共生细菌可以影响几种癌症模型中免疫检查点抑制剂的治疗效果。此外，检测肠道细菌的组成可以为预测免疫疗法的疗效和毒性提供依据。在这篇综述中，我们讨论了肠道共生细菌对肿瘤免疫微环境的影响，强调了一些典型细菌及其与免疫疗法的关联。
