Das Soumyajit, Chakraborty Suvamoy, Gupta Chamma, Lamichaney Rachna, Rahman Hafizur
Department of ENT, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, 5th Mile, Tadong, Gangtok - 737102, Sikkim, India.
Department of ENT, Neigrihms, Shillong, India.
Iran J Otorhinolaryngol. 2020 Mar;32(109):73-78. doi: 10.22038/ijorl.2019.35305.2163.
Iron plays an important role in myelination. Ferritin is a reliable indicator of the tissue iron store and umbilical cord ferritin level reflects the in utero iron stores. Objective is to study the effect of the umbilical cord ferritin level on the ABR recording in the newborn.
The study was conducted in a tertiary care hospital in India with a sample of 250. The study group was divided into Group A (with umbilical cord ferritin level of ≤ 75ng/ml) and Group B (umbilical cord ferritin level > 75ng/ml). Correlation analysis was carried out to study the relation between ferritin level and latency of wave I,III and V. Two sample t test was done between the two groups to study the significance of latency and amplitude of various ABR waves.
There was no correlation between the ferritin and ABR threshold as well as latency and amplitude of ABR waves. A significant prolongation of the absolute latency of wave V and the interwave latency of III - V and I -V of both the ears was found in Group A. The amplitude of the ABR waves did not show any statistical difference between the two groups.
Ferritin levels effect the latency of wave V of ABR and this may be attributed to slow conduction time secondary to altered myelination. Measurement of serum ferritin may be considered as a routine protocol in newborn babies after delivery or before discharge from hospital.
铁在髓鞘形成中起重要作用。铁蛋白是组织铁储存的可靠指标，脐带铁蛋白水平反映宫内铁储存情况。目的是研究脐带铁蛋白水平对新生儿听性脑干反应（ABR）记录的影响。
本研究在印度一家三级护理医院进行，样本量为250例。研究组分为A组（脐带铁蛋白水平≤75ng/ml）和B组（脐带铁蛋白水平>75ng/ml）。进行相关性分析以研究铁蛋白水平与I、III和V波潜伏期之间的关系。两组之间进行两样本t检验以研究各ABR波潜伏期和波幅的显著性。
铁蛋白与ABR阈值以及ABR波的潜伏期和波幅之间无相关性。A组双耳V波绝对潜伏期以及III - V和I - V的波间潜伏期显著延长。两组之间ABR波的波幅无统计学差异。
铁蛋白水平影响ABR的V波潜伏期，这可能归因于髓鞘形成改变导致的传导时间减慢。产后或出院前对新生儿测量血清铁蛋白可考虑作为常规检查项目。
