Sarin Vanita, Malhotra Preeti, Kaur Maninder Jeet, Kumar Ravishankar, Narang Gursharan Singh
Department of Otorhinolaryngology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, India.
Department of Paediatrics, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, India.
Indian J Otolaryngol Head Neck Surg. 2023 Sep;75(3):2201-2206. doi: 10.1007/s12070-023-03658-9. Epub 2023 May 6.
Iron is an important nutrient and it plays a pivotal role in myelin formation and neurotransmitter synthesis, thus contributing to normal neurological activity. Ferritin is a reliable indicator of the tissue iron stores and in-utero stores can be well measured by cord ferritin levels. The objective of this study was to evaluate the effects of umbilical cord ferritin levels (CFL) on the brain stem evoked response audiometry (BERA) This prospective observational study was conducted in a tertiary care centre of North India with a sample size of 100 inborn neonates. After evaluation of the umbilical cord ferritin levels the study cohort was divided into Group A( UCF<75ng/ml) and Group B(UCF>75ng/dl). All subjects were subjected to BERA. A detailed analysis of CFL and BERA was done and statistically analysed. Neonates in group B had significantly prolonged absolute peak latency of wave I, III and V and interpeak latency of wave III-V when compared to group A. The Pearson correlation also showed negative correlation of CFL with absolute peak latency of wave I, III, and V and interpeak latency of wave III-V. Among the maternal and neonatal variables, highly significant correlation was noted between absolute latency of wave I, III and V, CFL and cord hematocrit. The Pearson correlation showed negative correlation of absolute peak latency of wave I, III and V with maternal haemoglobin (Hb), neonatal birth weight, CFL,s and cord hematocrit values. A negative Pearson correlation was noted between interpeak latency of wave III-V with neonatal birth weight and cord hematocrit level, interpeak latency of wave I-V with neonatal birth weight and between interpeak latency of wave I-III with cord hematocrit values. CFL's significantly affect the absolute peak latency of wave I, III and V and it also affects the interpeak latency of wave III-V. This may be attributed to slow conduction time secondary to altered myelination. CFL's should be considered as a routine protocol in neonates to detect early compromises in the process of myelination and brain maturation.
铁是一种重要的营养素，它在髓鞘形成和神经递质合成中起关键作用，从而有助于正常的神经活动。铁蛋白是组织铁储存的可靠指标，宫内铁储存可以通过脐带铁蛋白水平进行很好的测量。本研究的目的是评估脐带铁蛋白水平（CFL）对脑干听觉诱发电位（BERA）的影响。这项前瞻性观察研究在印度北部的一家三级医疗中心进行，样本为100名足月儿。在评估脐带铁蛋白水平后，研究队列被分为A组（脐带铁蛋白<75ng/ml）和B组（脐带铁蛋白>75ng/dl）。所有受试者均接受脑干听觉诱发电位检查。对脐带铁蛋白水平和脑干听觉诱发电位进行了详细分析并进行统计学分析。与A组相比，B组新生儿的I、III和V波绝对峰潜伏期以及III-V波峰间潜伏期显著延长。Pearson相关性分析还显示，脐带铁蛋白水平与I、III和V波绝对峰潜伏期以及III-V波峰间潜伏期呈负相关。在母体和新生儿变量中，I、III和V波绝对潜伏期、脐带铁蛋白水平和脐带血细胞比容之间存在高度显著的相关性。Pearson相关性分析显示，I、III和V波绝对峰潜伏期与母体血红蛋白（Hb）、新生儿出生体重、脐带铁蛋白水平和脐带血细胞比容值呈负相关。III-V波峰间潜伏期与新生儿出生体重和脐带血细胞比容水平呈负Pearson相关性，I-V波峰间潜伏期与新生儿出生体重呈负Pearson相关性，I-III波峰间潜伏期与脐带血细胞比容值呈负Pearson相关性。脐带铁蛋白水平显著影响I、III和V波的绝对峰潜伏期，也影响III-V波的峰间潜伏期。这可能归因于髓鞘形成改变导致的传导时间减慢。在新生儿中，应将脐带铁蛋白水平视为检测髓鞘形成和脑成熟过程中早期损害的常规检查项目。
