Baudoin Olivier
University of Basel, Department of Chemistry, St. Johanns-Ring 19, CH-4056, Basel, Switzerland.
Angew Chem Int Ed Engl. 2020 Oct 5;59(41):17798-17809. doi: 10.1002/anie.202001224. Epub 2020 Aug 11.
In the past decade, multiple catalytic C-H bond functionalization has been successfully applied in natural product synthesis as a strategy to reduce the number of steps, increase overall yield and employ more easily available starting materials. This minireview presents selected examples making use of multiple C-H bond functionalization in conceptually different ways. First, linear syntheses are discussed, wherein multiple C-H functionalization is employed either from simple (hetero)cyclic cores, at a late stage, or to build polycyclic systems. Second, the use of multiple C-H functionalization as a strategic tool in convergent synthesis to access and couple complex fragments is discussed. Information on the scalability of the employed methods is provided when available. The presented cases indicate that multiple C-H functionalization strategies should play a great role to shape the future synthesis of functional complex molecules with improved sustainability.
在过去十年中，多重催化碳氢键官能团化已成功应用于天然产物合成，作为减少步骤数、提高总产率以及使用更易获得的起始原料的一种策略。本综述介绍了一些以概念上不同的方式利用多重碳氢键官能团化的实例。首先，讨论了线性合成，其中多重碳氢键官能团化要么从简单（杂）环核心出发，在后期进行，要么用于构建多环体系。其次，讨论了将多重碳氢键官能团化用作汇聚合成中的一种策略工具，以获取和偶联复杂片段。如有可用信息，还提供了所采用方法的可扩展性信息。所展示的实例表明，多重碳氢键官能团化策略在塑造未来具有更高可持续性的功能性复杂分子合成方面应发挥重要作用。
