Luan Rong-Sheng, Wang Xin, Sun Xin, Chen Xing-Shu, Zhou Tao, Liu Quan-Hui, Lü Xin, Wu Xian-Ping, Gu Dong-Qing, Tang Ming-Shuang, Cui Hui-Jie, Shan Xue-Feng, Ouyang Jing, Zhang Ben, Zhang Wei, Sichuan University Covid- Emergency Research Group
Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Department of Epidemiology and Biostatistics, the First Hospital Affiliated to AMU, Chongqing 400038, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2020 Mar;51(2):131-138. doi: 10.12182/20200360505.
This review summarizes the ongoing researches regarding etiology, epidemiology, transmission dynamics, treatment, and prevention and control strategies of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with comparison to severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and pandemic H1N1 virus. SARS-CoV-2 may be originated from bats, and the patients and asymptomatic carriers are the source of epidemic infection. The virus can be transmitted human-to-human through droplets and close contact, and people at all ages are susceptible to this virus. The main clinical symptoms of the patients are fever and cough, accompanied with leukocytopenia and lymphocytopenia. Effective drugs have been not yet available thus far. In terms of the prevention and control strategies, vaccine development as the primary prevention should be accelerated. Regarding the secondary prevention, ongoing efforts of the infected patients and close contacts quarantine, mask wearing promotion, regular disinfection in public places should be continued. Meanwhile, rapid detection kit for serological monitoring of the virus in general population is expected so as to achieve early detection, early diagnosis, early isolation and early treatment. In addition, public health education on this disease and prevention should be enhanced so as to mitigate panic and mobilize the public to jointly combat the epidemic.
本综述总结了关于严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的2019冠状病毒病(COVID-19)的病因、流行病学、传播动力学、治疗以及预防和控制策略的 ongoing 研究,并与严重急性呼吸综合征冠状病毒(SARS-CoV)、中东呼吸综合征冠状病毒(MERS-CoV)和大流行H1N1病毒进行了比较。SARS-CoV-2可能起源于蝙蝠,患者和无症状携带者是疫情感染源。该病毒可通过飞沫和密切接触在人际间传播,各年龄段人群均对该病毒易感。患者的主要临床症状为发热和咳嗽,伴有白细胞减少和淋巴细胞减少。目前尚无有效的药物。在预防和控制策略方面,应加速作为主要预防手段的疫苗研发。在二级预防方面,应继续对感染患者和密切接触者进行隔离、推广佩戴口罩、在公共场所定期消毒。同时,期望有针对普通人群进行病毒血清学监测的快速检测试剂盒,以实现早发现、早诊断、早隔离和早治疗。此外,应加强对该疾病及其预防的公众健康教育,以减轻恐慌并动员公众共同抗击疫情。