Department of Radiology, Beijing Jishuitan Hospital, Beijing 100035, China.
Medical Research and Biometrics Center, National Center for Cardiovascular Disease, Beijing 102300, China.
Aging (Albany NY). 2020 Mar 28;12(6):5500-5515. doi: 10.18632/aging.102974.
The effect of calcium on prevention of osteoporosis and related fracture which are aging issues is unclear. The aim of this study is to explore the association of calcium intake with vertebral fracture. This study enrolled 3,457 participants from China Action on Spine and Hip Status (CASH) study from 2013 and 2017. Dietary calcium intake was collected using validated food frequency questionnaires (FFQ). Vertebral fracture of CT images was defined as the primary outcome. The mean calcium intake of men and women were 522.75mg/day and 507.21mg/day, respectively. 6% reduction in the odds of fracture risk was observed per 100 unit increase of calcium intake from food among females (OR, 0.94; 95% CI, 0.89-0.99), but results among males were not significant. We divided calcium intake into quintiles when modelling its associations with fracture risk, negative associations of fracture risk with calcium intake were found among females. In a population with low usual calcium intake, higher dietary calcium intake was associated with fewer vertebral fracture in women and that no such association was seen in men.
钙对预防与衰老有关的骨质疏松症和相关骨折的影响尚不清楚。本研究旨在探讨钙摄入量与椎体骨折的关系。本研究纳入了 2013 年至 2017 年中国脊柱和髋关节状况行动（CASH）研究中的 3457 名参与者。采用经过验证的食物频率问卷（FFQ）收集膳食钙摄入量。CT 图像上的椎体骨折为主要结局。男性和女性的平均钙摄入量分别为 522.75mg/天和 507.21mg/天。女性中，钙摄入量每增加 100 个单位，骨折风险降低 6%（OR，0.94；95%CI，0.89-0.99），但男性结果不显著。在对骨折风险与钙摄入量的关系进行建模时，我们将钙摄入量分为五组，发现女性骨折风险与钙摄入量呈负相关。在通常钙摄入量较低的人群中，较高的膳食钙摄入量与女性较少发生椎体骨折相关，而男性则没有这种关联。
