LMP2和LMP7基因多态性与胰岛素依赖型糖尿病易感性之间的遗传关联：一项荟萃分析。

The genetic association between LMP2 and LMP7 polymorphisms and susceptibility of insulin dependent diabetes mellitus: A meta-analysis.

作者信息

Xu Yang, Liu Guotao, Zhou Yv, Lu Zengzhen, Shi Zhaorui, Wang Jun

机构信息

Department of Endocrinology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.

出版信息

Medicine (Baltimore). 2020 Mar;99(13):e19482. doi: 10.1097/MD.0000000000019482.

DOI:10.1097/MD.0000000000019482

PMID:32221071

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7220142/

Abstract

BACKGROUND

Insulin dependent diabetes mellitus (IDDM) is a kind of heterogeneous disease caused by the interaction of polygene inheritance and environmental factors. The LMP2 and LMP7 are 2 loci in LMP gene, and although genetic association between LMP2 and LMP7 polymorphisms were reported, the results are inconclusive. The aim of this study was to investigate the association between LMP2 and LMP7 polymorphisms and IDDM risk.

METHODS

An exhaustive search was performed out through the electronic databases including PubMed, Embase, and Chinese National Knowledge Infrastructure (CNKI). The pooled odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength association between LMP2 CfoI and LMP7 G37360T polymorphisms and IDDM risk.

RESULTS

A total of 7 studies with 707 cases and 821 controls were included in the present study. The results indicated that the dominant model of LMP2 CfoI was significantly associated with IDDM in Asian population (OR = 1.96, 95% CI: 1.24-3.10, P = .004). In addition, the allelic and dominant models of LMP7 G37360T were associated with IDDM in Caucasian population (allelic model: OR = 0.69, 95% CI: 0.56-0.85, P = .0005; dominant model: OR = 0.67, 95% CI: 0.50-0.89, P = .007).

CONCLUSIONS

The dominant model of LMP2 CfoI might be a risk factor for IDDM in Asian population. Whereas, the allelic and dominant models of LMP7 G37360T might be protective factors for IDDM in Caucasian population.

摘要

背景

胰岛素依赖型糖尿病（IDDM）是一种由多基因遗传与环境因素相互作用引起的异质性疾病。LMP2和LMP7是LMP基因中的两个基因座，尽管有报道称LMP2和LMP7多态性之间存在遗传关联，但结果尚无定论。本研究的目的是探讨LMP2和LMP7多态性与IDDM风险之间的关联。

方法

通过电子数据库进行全面检索，包括PubMed、Embase和中国知网（CNKI）。采用合并比值比（OR）和95%置信区间（CI）来评估LMP2 CfoI和LMP7 G37360T多态性与IDDM风险之间的关联强度。

结果

本研究共纳入7项研究，包括707例病例和821例对照。结果表明，LMP2 CfoI的显性模型在亚洲人群中与IDDM显著相关（OR = 1.96，95% CI：1.24 - 3.10，P = 0.004）。此外，LMP7 G37360T的等位基因模型和显性模型在白种人群中与IDDM相关（等位基因模型：OR = 0.69，95% CI：0.56 - 0.85，P = 0.0005；显性模型：OR = 0.67，95% CI：0.50 - 0.89，P = 0.007）。