雌激素和孕酮对人胎盘去甲肾上腺素代谢失活的影响。

Effect of oestrogens and progesterone on the metabolic inactivation of noradrenaline in the human placenta.

作者信息

Saarikoski S

机构信息

Department of Obstetrics and Gynaecology, University Central Hospital, Kuopio, Finland.

出版信息

Placenta. 1988 Sep-Oct;9(5):507-12. doi: 10.1016/0143-4004(88)90023-9.

DOI:10.1016/0143-4004(88)90023-9

PMID:3222223

Abstract

The enzymatic inactivation of noradrenaline was investigated in 25 fresh human placentae in vitro. Oxidative deamination by monoamine oxidase (MAO) was greater than enzymic O-methylation by catechol-O-methyltransferase (COMT). The addition of oestriol (E3) or progesterone to the organ bath significantly decreased (P less than 0.001) the activity of placental MAO. Oestrone (E1) and oestradiol (E2) showed no inhibitory effect. In addition, E3 significantly inhibited the activity of COMT (P less than 0.001), whereas oestrone and oestradiol had no effect on COMT activity. COMT was also inhibited by progesterone (P less than 0.05). The decrease in enzymic inactivation of noradrenaline caused by oestriol and progesterone suggests an activated adrenoceptor function.

摘要

在25个新鲜人胎盘体外实验中研究了去甲肾上腺素的酶促失活情况。单胺氧化酶（MAO）介导的氧化脱氨作用比儿茶酚-O-甲基转移酶（COMT）介导的酶促O-甲基化作用更强。向器官浴中添加雌三醇（E3）或孕酮可显著降低（P<0.001）胎盘MAO的活性。雌酮（E1）和雌二醇（E2）未显示出抑制作用。此外，E3显著抑制COMT的活性（P<0.001），而雌酮和雌二醇对COMT活性无影响。孕酮也可抑制COMT（P<0.05）。雌三醇和孕酮导致的去甲肾上腺素酶促失活减少提示肾上腺素能受体功能被激活。