[大鼠体内地那维林（斯帕司林）的生物转化]
[Biotransformation of denaverin (Spasmalgan) in the rat].
作者信息
Göber B, Lisowski H, Friese D, Franke P
机构信息
Sektion Chemie, Wissenschaftsbereich Pharmazie, Humboldt-Universität zu Berlin.
出版信息
Pharmazie. 1988 Jul;43(7):493-5.
After oral application of denaverine hydrochloride to rats (200-250 mg/kg) 12 metabolites have been detectecd in urine. Besides the unchanged drug, 8 metabolites were identified by MS as 2,2-diphenyl-(2-dimethylaminoethyl) acetate (3), diphenylacetic (5) and benzilic acid (6); methyl-and ethyl [2-(2-ethylbutoxy)-2,2-diphenyl]acetate (7, 11), methylbenzilate (10), N-demethyl-1 (12) and 3,3-diphenyl-morpholin-2-one (13). 6 and the metabonate 13 represent the main metabolic products. Compounds 7 and 11 indicate the metabolic pathway about an alkoxybenzilic acid (4). Phenols resp. conjugates were not detected.
给大鼠口服盐酸地那维林（200 - 250 mg/kg）后，在尿液中检测到12种代谢产物。除了未变化的药物外，通过质谱鉴定出8种代谢产物，分别为2,2 - 二苯基 -（2 - 二甲基氨基乙基）乙酸酯（3）、二苯基乙酸（5）和二苯乙醇酸（6）；甲基和乙基[2 -（2 - 乙基丁氧基）- 2,2 - 二苯基]乙酸酯（7, 11）、甲基二苯乙醇酸酯（10）、N - 去甲基 - 1（12）和3,3 - 二苯基 - 吗啉 - 2 - 酮（13）。6和代谢产物13是主要代谢产物。化合物7和11表明了关于烷氧基二苯乙醇酸（4）的代谢途径。未检测到酚类及结合物。
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