转录组学：治疗肾性骨营养不良的新方法？
Transcriptomics: a Solution for Renal Osteodystrophy?
机构信息
Division of Nephrology and Hypertension, Center for Translational Metabolism and Health and Feinberg Cardiovascular and Renal Research Institute, Northwestern University, 320 East Superior Street, Chicago, IL, 60611, USA.
出版信息
Curr Osteoporos Rep. 2020 Jun;18(3):254-261. doi: 10.1007/s11914-020-00583-6.
PURPOSE OF REVIEW
The molecular mechanisms of the bone disease associated with chronic kidney disease (CKD), called renal osteodystrophy (ROD), are poorly understood. New transcriptomics technologies may provide clinically relevant insights into the pathogenesis of ROD. This review summarizes current progress and limitations in the study and treatment of ROD, and in transcriptomics analyses of skeletal tissues.
RECENT FINDINGS
ROD is characterized by poor bone quality and strength leading to increased risk of fracture. Recent studies indicate permanent alterations in bone cell populations during ROD. Single-cell transcriptomics analyses, successful at identifying specialized cell subpopulations in bone, have not yet been performed in ROD. ROD is a widespread poorly understood bone disease with limited treatment options. Transcriptomics analyses of bone are needed to identify the bone cell subtypes and their role in the pathogenesis of ROD, and to develop adequate diagnosis and treatment strategies.
目的综述
慢性肾脏病（CKD）相关的骨病，即肾性骨营养不良（ROD）的分子机制尚不清楚。新的转录组学技术可能为 ROD 的发病机制提供临床相关的见解。本综述总结了 ROD 的研究和治疗以及骨骼组织转录组学分析方面的最新进展和局限性。
最近的发现
ROD 的特征是骨质量和强度差，导致骨折风险增加。最近的研究表明，ROD 期间骨细胞群体发生了永久性改变。单细胞转录组学分析成功地鉴定了骨中的特化细胞亚群，但尚未在 ROD 中进行。ROD 是一种广泛存在但知之甚少的骨病，治疗选择有限。需要对骨骼进行转录组学分析，以确定骨细胞亚型及其在 ROD 发病机制中的作用，并制定出适当的诊断和治疗策略。
Zotero 插件