实验噬菌体疗法在伴侣动物中的应用：历史回顾。
Experimental Phage Therapies in Companion Animals with A Historical Review.
机构信息
Sub-Department of Veterinary Prevention and Avian Diseases, Institute of Biological Basis of Animal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033, Lublin, Poland.
Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033, Lublin, Poland.
出版信息
Curr Rev Clin Exp Pharmacol. 2021;16(1):17-29. doi: 10.2174/1574884715666200330105411.
BACKGROUND
The aim of the review was to comprehensively characterize the antimicrobial efficacy of bacteriophages in eliminating pathogens occurring in companion animals, as an alternative to antibiotics for controlling infections that pose potential threats to the health and life of people and to the environment.
METHODS
The review contains detailed information on the characteristics and classification of bacteriophages and an analysis of their life cycle. The dominant element is a detailed analysis of the experimental use of bacteriophages in combating infections caused by various microorganisms in companion animals with regard to their potential use in therapy.
RESULTS
It seems that in the near future, phage therapies will provide an alternative to antibiotics in the treatment of diseases caused by multi-drug resistant bacteria in people and animals.
CONCLUSIONS
The effectiveness of phage therapies depends on many factors and the properties of the bacteriophages themselves, which requires comprehensive knowledge of them.
背景
本综述旨在全面描述噬菌体在消除伴侣动物中病原体方面的抗菌功效，作为控制对人类健康和生命以及环境构成潜在威胁的感染的抗生素替代品。
方法
本综述包含了有关噬菌体的特性和分类的详细信息，并分析了它们的生命周期。主要内容是详细分析噬菌体在治疗伴侣动物中由各种微生物引起的感染方面的实验应用，以及它们在治疗中的潜在用途。
结果
在不久的将来，噬菌体疗法似乎将成为治疗人和动物中多药耐药菌引起的疾病的抗生素替代品。
结论
噬菌体疗法的有效性取决于许多因素和噬菌体本身的特性，这需要对它们有全面的了解。
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