Ferriol-González Celia, Domingo-Calap Pilar
Department of Genetics, Universitat de València, 46100 Valencia, Spain.
Institute for Integrative Systems Biology, I2SysBio, Universitat de València-CSIC, 46980 Valencia, Spain.
Antibiotics (Basel). 2021 May 11;10(5):559. doi: 10.3390/antibiotics10050559.
The irrational use of antibiotics has led to a high emergence of multi-drug resistant (MDR) bacteria. The traditional overuse of antibiotics in the animal feed industry plays a crucial role in the emergence of these pathogens that pose both economic and health problems. In addition, antibiotics have also recently experienced an increase to treat companion animal infections, promoting the emergence of MDR bacteria in pets, which can reach humans. Phages have been proposed as an alternative for antibiotics for the treatment of livestock and companion animal infections due to their multiple advantages as adaptative drugs, such as their ability to evolve, to multiply at the site of infections, and their high specificity. Moreover, phage-derived enzymes may also be an interesting approach. However, the lack of regulation for this type of pharmaceutical hinders its potential commercialization. In this review, we summarize the main recent studies on phage therapy in livestock and companion animals, providing an insight into current advances in this area and the future of treatments for bacterial infections.
抗生素的不合理使用导致了多重耐药（MDR）细菌的大量出现。动物饲料行业传统上过度使用抗生素，在这些引发经济和健康问题的病原体出现过程中起到了关键作用。此外，抗生素在治疗伴侣动物感染方面的使用近来也有所增加，这促使宠物中出现多重耐药细菌，而这些细菌可能传播给人类。由于噬菌体作为适应性药物具有多种优势，如能够进化、在感染部位繁殖以及具有高度特异性，因此已被提议作为抗生素的替代品用于治疗家畜和伴侣动物感染。此外，噬菌体衍生的酶也可能是一种有趣的方法。然而，这类药物缺乏监管阻碍了其潜在的商业化。在本综述中，我们总结了近期关于家畜和伴侣动物噬菌体疗法的主要研究，深入了解该领域的当前进展以及细菌感染治疗的未来发展。
