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Phage Delivery Strategies for Biocontrolling Human, Animal, and Plant Bacterial Infections: State of the Art.

作者信息

Vila Marta M D C, Balcão Liliane M N, Balcão Victor M

机构信息

VBlab-Laboratory of Bacterial Viruses, University of Sorocaba, Sorocaba 18023-000, SP, Brazil.

Department of Biology and CESAM, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.

出版信息

Pharmaceutics. 2024 Mar 8;16(3):374. doi: 10.3390/pharmaceutics16030374.


DOI:10.3390/pharmaceutics16030374
PMID:38543268
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10976114/
Abstract

This review aims at presenting the main strategies that are currently available for the delivery of bacteriophages to combat bacterial infections in humans, animals, and plants. It can be seen that the main routes for phage delivery are topical, oral, systemic, and airways for humans. In animals, the topical and oral routes are the most used. To combat infections in plant species, spraying the plant's phyllosphere or drenching the soil are the most commonly used methods. In both phage therapy and biocontrol using phages, very promising results have been obtained so far. However, more experiments are needed to establish forms of treatment and phage doses, among other parameters. Furthermore, in general, there is a lack of specific standards for the use of phages to combat bacterial infections.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a35/10976114/12570be32c90/pharmaceutics-16-00374-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a35/10976114/8296f08897cc/pharmaceutics-16-00374-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a35/10976114/4d627af2649c/pharmaceutics-16-00374-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a35/10976114/bccb2691b504/pharmaceutics-16-00374-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a35/10976114/12570be32c90/pharmaceutics-16-00374-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a35/10976114/8296f08897cc/pharmaceutics-16-00374-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a35/10976114/4d627af2649c/pharmaceutics-16-00374-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a35/10976114/bccb2691b504/pharmaceutics-16-00374-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a35/10976114/12570be32c90/pharmaceutics-16-00374-g004.jpg

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[5]
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[6]
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[7]
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本文引用的文献

[1]
Alginate microbeads and hydrogels delivering meropenem and bacteriophages to treat Pseudomonas aeruginosa fracture-related infections.

J Control Release. 2023-12

[2]
Phages and Nanotechnology: New Insights against Multidrug-Resistant Bacteria.

Biodes Res. 2023-1-16

[3]
Newly isolated phages preying on Pseudomonas syringae pv. garcae: In vitro and ex vivo inactivation studies in coffee plant leafs.

Enzyme Microb Technol. 2023-12

[4]
Biological and Genetic Characterizations of a Novel Lytic ΦFifi106 against Indigenous and Evaluation of the Control of Fire Blight in Apple Plants.

Biology (Basel). 2023-7-28

[5]
Isolation, characterization, and evaluation of putative new bacteriophages for controlling bacterial spot on tomato in Brazil.

Arch Virol. 2023-8-7

[6]
Bacteriophages in Infectious Diseases and Beyond-A Narrative Review.

Antibiotics (Basel). 2023-6-5

[7]
An Edible Biopolymeric Microcapsular Wrapping Integrating Lytic Bacteriophage Particles for : Potential for Integration into Poultry Feed.

Antibiotics (Basel). 2023-5-31

[8]
The current status of phage therapy and its advancement towards establishing standard antimicrobials for combating multi drug-resistant bacterial pathogens.

Microb Pathog. 2023-8

[9]
Translating phage therapy into the clinic: Recent accomplishments but continuing challenges.

PLoS Biol. 2023-5

[10]
Single-arm, open-labelled, safety and tolerability of intrabronchial and nebulised bacteriophage treatment in children with cystic fibrosis and .

BMJ Open Respir Res. 2023-5

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