Professor, Academic Department of Psychiatry, Northern Sydney Local Health District; Advanced Research and Clinical High-Field Imaging, Sydney Medical School Northern, The University of Sydney; Discipline of Psychiatry, Sydney Medical School Northern, The University of Sydney; and CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, Australia.
Senior Research Fellow, Academic Department of Psychiatry, Northern Sydney Local Health District; Advanced Research and Clinical High-Field Imaging, Sydney Medical School Northern, The University of Sydney; Discipline of Psychiatry, Sydney Medical School Northern, The University of Sydney; and CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, Australia.
Br J Psychiatry. 2020 Jul;217(1):383-389. doi: 10.1192/bjp.2019.255.
Adolescent subthreshold emotional symptoms arise from impaired self-referential information-processing and approach-avoidance behaviour network integration, which compromises goal evaluation and pursuit strategies.
We investigated whether impairment of negative emotion (goal) reappraisal strategies (self-focussing and self-distancing) generates emotional symptoms (emotional disorders precursors).
Using functional magnetic resonance imaging and a triple-network model (default mode, executive control and salience), functional connectivity differences within and between networks, and their modulation by task and relationships with emotional symptoms were determined in healthy adolescent girls (N = 202) grouped by presence or absence of emotional symptoms.
The groups differed in spectral power distribution and in dorsal default mode network and right executive control network modulation when self-focussing and self-distancing, respectively. Girls without emotional symptoms had greater spectral power and less network modulation. Greater spectral power was associated with reduced emotional symptoms and less dorsal default mode network modulation when self-focussing.
The early phases of anxiety and depressive disorders in adolescence are marked by emotional symptoms that usually emerge in the context of negative life events. To contend with the negative effect of such events, a typical reappraisal strategy is to distance oneself and switch the focus of one's thinking. This brain-imaging study in adolescent girls prone to the development of emotional disorders has found functional changes in key neural networks that are involved in reappraisal and shown that this process is impaired. This is important because it provides an early indication of these common disorders and a potential target for psychological interventions.
青少年亚临床情绪症状源于自我参照信息处理和趋近-回避行为网络整合受损，这会影响目标评估和追求策略。
我们研究了消极情绪（目标）再评价策略（自我关注和自我抽离）的损伤是否会产生情绪症状（情绪障碍的前兆）。
使用功能磁共振成像和三重网络模型（默认模式、执行控制和突显网络），我们确定了有或无情绪症状的健康青少年女孩（N=202）组内和组间网络的功能连接差异，以及任务和情绪症状之间的关系。
两组在自我关注和自我抽离时的频谱功率分布以及背侧默认模式网络和右侧执行控制网络的调制存在差异。无情绪症状的女孩频谱功率更高，网络调制更少。当自我关注时，更大的频谱功率与更少的情绪症状和背侧默认模式网络调制有关。
青少年焦虑和抑郁障碍的早期阶段以情绪症状为特征，这些症状通常出现在负面生活事件的背景下。为了应对这种负面事件的影响，一种典型的再评价策略是自我抽离，将思维焦点转移。这项针对易发生情绪障碍的青春期女孩的大脑成像研究发现，参与再评价的关键神经网络存在功能变化，并表明这一过程受损。这很重要，因为它提供了这些常见障碍的早期迹象和心理干预的潜在目标。
