Zhongzhi International Institute of Agricultural Biosciences, Biology and Agriculture Research Center, University of Science and Technology Beijing, Beijing 100024, China.
Beijing Engineering Laboratory of Main Crop Bio-Tech Breeding, Beijing International Science and Technology Cooperation Base of Bio-Tech Breeding, Beijing Solidwill Sci-Tech Co. Ltd., Beijing 100192, China.
Int J Mol Sci. 2020 Mar 26;21(7):2278. doi: 10.3390/ijms21072278.
Lateral organ boundaries (LOB) domain () genes, a gene family encoding plant-specific transcription factors, play important roles in plant growth and development. At present, though there have been a number of genome-wide analyses on gene families and functional studies on individual LBD proteins, the diverse functions of LBD family members still confuse researchers and an effective strategy is required to summarize their functional diversity. To further integrate and improve our understanding of the phylogenetic classification, functional characteristics and regulatory mechanisms of LBD proteins, we review and discuss the functional characteristics of LBD proteins according to their classifications under a phylogenetic framework. It is proved that this strategy is effective in the anatomy of diverse functions of LBD family members. Additionally, by phylogenetic analysis, one monocot-specific and one eudicot-specific subclade of LBD proteins were found and their biological significance in monocot and eudicot development were also discussed separately. The review will help us better understand the functional diversity of LBD proteins and facilitate further studies on this plant-specific transcription factor family.
侧生器官边界（LOB）结构域（）基因是一类编码植物特异性转录因子的基因家族，在植物生长和发育中发挥重要作用。目前，虽然已经对基因家族进行了大量的全基因组分析，并对个别 LBD 蛋白进行了功能研究，但 LBD 家族成员的多种功能仍困扰着研究人员，需要采取有效的策略来总结其功能多样性。为了进一步综合和提高我们对 LBD 蛋白系统发生分类、功能特征和调控机制的理解，我们根据系统发生框架下的分类，综述和讨论了 LBD 蛋白的功能特征。事实证明，这种策略在解析 LBD 家族成员的多种功能方面是有效的。此外，通过系统发生分析，发现了 LBD 蛋白的一个单子叶植物特异性和一个双子叶植物特异性亚家族，并分别讨论了它们在单子叶植物和双子叶植物发育中的生物学意义。该综述将有助于我们更好地理解 LBD 蛋白的功能多样性，并促进对这个植物特异性转录因子家族的进一步研究。
