大鼠器官光声成像中可见近红外一区（NIR-I）和近红外二区（NIR-II）光穿透的评估。
Evaluation of visible NIR-I and NIR-II light penetration for photoacoustic imaging in rat organs.
作者信息
Sun Aihui, Guo Heng, Gan Qi, Yang Lei, Liu Qiang, Xi Lei
出版信息
Opt Express. 2020 Mar 16;28(6):9002-9013. doi: 10.1364/OE.389714.
In this study, we evaluate the penetration capability of light in visible, near-infrared-I (NIR-I) and near-infrared-II (NIR-II) optical windows for photoacoustic macroscale imaging inside 9 biological tissues with three typical penetration depths. An acoustic resolution photoacoustic microscopy is designed to guarantee the consistent experiment conditions except excitation wavelength. Experimental results show that short NIR-II (1000-1150 nm) shows the best performance inside kidney, spleen and liver tissues at all depths, while NIR-I (700-1000 nm) works better for muscle, stomach, heart and brain tissues, especially in deep imaging. This study proposes the optimal selection of illumination wavelengths for photoacoustic macroscale imaging in rat organs, which enables the best signal-to-noise ratio (SNR) of the observed target.
在本研究中，我们评估了可见光、近红外-I（NIR-I）和近红外-II（NIR-II）光学窗口中的光在具有三种典型穿透深度的9种生物组织内进行光声宏观成像时的穿透能力。设计了一种声学分辨率光声显微镜，以确保除激发波长外的实验条件一致。实验结果表明，短近红外-II（1000 - 1150 nm）在所有深度下在肾脏、脾脏和肝脏组织中表现最佳，而近红外-I（700 - 1000 nm）对肌肉、胃、心脏和脑组织效果更好，尤其是在深度成像方面。本研究提出了大鼠器官光声宏观成像照明波长的最佳选择，这能够使观察目标具有最佳的信噪比（SNR）。
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