基于核酸碱基三联体的冠状病毒系统发育

Liao Bo, Liu Yanshu, Li Renfa, Zhu Wen

Laboratory of Embedded Computing and System, School of Computer and Communication, Hunan University, Changsha, Hunan 410082, China.

Chem Phys Lett. 2006 Apr 15;421(4):313-318. doi: 10.1016/j.cplett.2006.01.030. Epub 2006 Feb 20.

We considered the fully overlapping triplets of nucleotide bases and proposed a 2D graphical representation of protein sequences consisting of 20 amino acids and a stop code. Based on this 2D graphical representation, we outlined a new approach to analyze the phylogenetic relationships of coronaviruses by constructing a covariance matrix. The evolutionary distances are obtained through measuring the differences among the two-dimensional curves.

我们考虑了核苷酸碱基的完全重叠三联体，并提出了一种由20种氨基酸和一个终止密码组成的蛋白质序列的二维图形表示法。基于这种二维图形表示法，我们概述了一种通过构建协方差矩阵来分析冠状病毒系统发育关系的新方法。进化距离是通过测量二维曲线之间的差异获得的。