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新生儿败血症

Neonatal Sepsis.

作者信息

Ershad Muhammed, Mostafa Ahmed, Dela Cruz Maricel, Vearrier David

机构信息

College of Medicine, Drexel University, 245 N 15th St, MS #1011, Philadelphia, PA 19102 USA.

出版信息

Curr Emerg Hosp Med Rep. 2019;7(3):83-90. doi: 10.1007/s40138-019-00188-z. Epub 2019 Jun 19.

DOI:10.1007/s40138-019-00188-z
PMID:32226657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7100521/
Abstract

PURPOSE OF REVIEW

Neonatal sepsis is a diagnosis made in infants less than 28 days of life and consists of a clinical syndrome that may include systemic signs of infection, circulatory shock, and multisystem organ failure.

RECENT FINDINGS

Commonly involved bacteria include and . Risk factors include central venous catheter use and prolonged hospitalization. Neonates are at significant risk of delayed recognition of sepsis until more ominous clinical findings and vital sign abnormalities develop. Blood culture remains the gold standard for diagnosis.

SUMMARY

Neonatal sepsis remains an important diagnosis requiring a high index of suspicion. Immediate treatment with antibiotics is imperative.

摘要

综述目的

新生儿败血症是指出生28天以内婴儿的一种诊断,其包括一种临床综合征,可能有感染的全身症状、循环性休克和多系统器官衰竭。

最新发现

常见的感染细菌包括……和……。危险因素包括使用中心静脉导管和住院时间延长。在出现更严重的临床症状和生命体征异常之前,新生儿败血症很容易被漏诊。血培养仍然是诊断的金标准。

总结

新生儿败血症仍然是一个需要高度怀疑指数的重要诊断。必须立即使用抗生素进行治疗。

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Accuracy of presepsin in neonatal sepsis: systematic review and meta-analysis.降钙素原在新生儿败血症中的准确性:系统评价和荟萃分析。
Expert Rev Anti Infect Ther. 2019 Apr;17(4):223-232. doi: 10.1080/14787210.2019.1584037. Epub 2019 Mar 8.
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Management of Neonates Born at ≥35 0/7 Weeks' Gestation With Suspected or Proven Early-Onset Bacterial Sepsis.胎龄≥35 周的疑似或确诊早发性细菌性败血症新生儿的处理。
Pediatrics. 2018 Dec;142(6). doi: 10.1542/peds.2018-2894.
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Risk Factors for Neonatal Sepsis in Pregnant Women with Premature Rupture of the Membrane.胎膜早破孕妇发生新生儿败血症的危险因素
J Pregnancy. 2018 Oct 1;2018:4823404. doi: 10.1155/2018/4823404. eCollection 2018.
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Culture-Negative Early-Onset Neonatal Sepsis - At the Crossroad Between Efficient Sepsis Care and Antimicrobial Stewardship.培养阴性早发型新生儿败血症——高效败血症护理与抗菌药物管理的十字路口
Front Pediatr. 2018 Oct 9;6:285. doi: 10.3389/fped.2018.00285. eCollection 2018.
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Precision Medicine for Neonatal Sepsis.新生儿败血症的精准医学
Front Mol Biosci. 2018 Jul 26;5:70. doi: 10.3389/fmolb.2018.00070. eCollection 2018.
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Neonatal Sepsis of Early Onset, and Hospital-Acquired and Community-Acquired Late Onset: A Prospective Population-Based Cohort Study.早发型新生儿败血症、医院获得性晚发型和社区获得性晚发型败血症:一项前瞻性基于人群的队列研究。
J Pediatr. 2018 Oct;201:106-114.e4. doi: 10.1016/j.jpeds.2018.05.048. Epub 2018 Jul 24.
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The global burden of paediatric and neonatal sepsis: a systematic review.全球儿童和新生儿脓毒症负担:系统评价。
Lancet Respir Med. 2018 Mar;6(3):223-230. doi: 10.1016/S2213-2600(18)30063-8.
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Procalcitonin use for shorter courses of antibiotic therapy in suspected early-onset neonatal sepsis: are we getting there?降钙素原用于疑似早发型新生儿败血症的短疗程抗生素治疗:我们正在实现这一目标吗?
J Thorac Dis. 2017 Dec;9(12):4899-4902. doi: 10.21037/jtd.2017.11.80.
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Race, Income and Insurance Status Affect Neonatal Sepsis Mortality and Healthcare Resource Utilization.种族、收入和保险状况影响新生儿败血症的死亡率和医疗资源利用。
Pediatr Infect Dis J. 2018 Jul;37(7):e178-e184. doi: 10.1097/INF.0000000000001846.
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Emerg Nurse. 2017 Oct 12;25(6):23-29. doi: 10.7748/en.2017.e1704.