Lutter Ferdinand H, Grokenberger Lucie, Benz Maximilian, Knochel Paul
Department für Chemie und Pharmazie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 Munich, Germany.
Org Lett. 2020 Apr 17;22(8):3028-3032. doi: 10.1021/acs.orglett.0c00795. Epub 2020 Mar 31.
A mild cobalt-catalyzed Negishi-type cross-coupling of various functionalized dialkylzinc reagents with primary and secondary alkyl iodides in acetonitrile is reported using a combination of 20% CoCl and chelating nitrogen ligands. The method allows the construction of molecules with alkyl chains bearing sensitive functional groups at room temperature.
据报道，使用20%的CoCl和螯合氮配体的组合，在乙腈中各种功能化二烷基锌试剂与伯烷基和仲烷基碘化物能进行温和的钴催化Negishi型交叉偶联反应。该方法能够在室温下构建带有敏感官能团烷基链的分子。
