我们都知道我们需要它们，我们希望它们会来，但什么时候呢？
We All Know We Need Them, We Hope They Are Coming, But When?
机构信息
Section of Adult and Pediatric Endocrinology and Metabolism, University of Chicago, Chicago, Illinois, USA.
出版信息
Thyroid. 2020 Jun;30(6):791-793. doi: 10.1089/thy.2020.0250. Epub 2020 Apr 28.
Abstract
A number of mechanisms modify thyroid hormone (TH) signaling at the cellular level. To restore TH signaling in patients with hypothyroidism or in patients with the syndrome of TH resistance, it is necessary to quantify the action of THs in a tissue-specific manner. The development of biomarkers that are tissue-specific and respond to TH is a significant first step toward understanding and possibly modifying TH signaling in health and disease states.
摘要
许多机制在细胞水平上调节甲状腺激素（TH）信号。为了恢复甲状腺功能减退症患者或甲状腺激素抵抗综合征患者的 TH 信号，有必要以组织特异性的方式量化 TH 的作用。开发组织特异性且对 TH 有反应的生物标志物是理解和可能修饰健康和疾病状态下 TH 信号的重要第一步。
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