NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Department of Hematology, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China.
Leuk Lymphoma. 2020 Aug;61(8):1989-1995. doi: 10.1080/10428194.2020.1742910. Epub 2020 Mar 31.
The Sanz risk, which was originally used to predict the risk of acute promyelocytic leukemia (APL) relapse, is a recognized method to predict the prognosis of APL. About 570 APL patients admitted to our center were randomly divided into a training cohort ( = 344) and validation cohort ( = 226). Multivariate analysis of training cohort demonstrated that age >52 (OR = 5.170, = .002), white blood cell count >10 × 10/L (OR = 9.062, < .001), PLT count ≤10 × 10/L (OR = 4.254, < .001), and LDH level >500 U/L (OR= 3.002, = .046) were independent risk factors for early death. A risk score (age >52: 1.5 points; WBC >10 × 10/L: 2 points; PLT ≤10 × 10/L: 1 point; LDH >500 U/L: 1 point) was used to predict early death risk. The model shows a better predictive power of early death in training cohort and validation cohort compared with Sanz risk stratification.
Sanz 风险最初用于预测急性早幼粒细胞白血病 (APL) 复发的风险，是一种公认的预测 APL 预后的方法。约 570 名入住我院的 APL 患者被随机分为训练队列（n=344）和验证队列（n=226）。对训练队列的多因素分析表明，年龄>52 岁（OR=5.170，P=.002）、白细胞计数>10×10/L（OR=9.062，P<.001）、血小板计数≤10×10/L（OR=4.254，P<.001）和乳酸脱氢酶（LDH）水平>500 U/L（OR=3.002，P=.046）是早期死亡的独立危险因素。采用风险评分（年龄>52 岁：1.5 分；白细胞计数>10×10/L：2 分；血小板计数≤10×10/L：1 分；LDH>500 U/L：1 分）预测早期死亡风险。该模型在训练队列和验证队列中均显示出比 Sanz 风险分层更好的早期死亡预测能力。
