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黄体血流作为预测未破裂输卵管妊娠患者甲氨蝶呤治疗结局的因素。

Luteal blood flow as a predictive factor for methotrexate treatment outcomes in women with unruptured tubal pregnancy.

机构信息

Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.

出版信息

BMC Pregnancy Childbirth. 2020 Mar 30;20(1):190. doi: 10.1186/s12884-020-02882-3.

DOI:10.1186/s12884-020-02882-3
PMID:32228498
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7106736/
Abstract

BACKGROUND

Blood flow in the corpus luteum is associated with luteal function. However, the impact of luteal blood flow on methotrexate (MTX) treatment in women with unruptured tubal pregnancy has not been reported. The aim of the present study was to observe the impact of luteal blood flow on the therapeutic effect of MTX in women with unruptured tubal pregnancy.

METHODS

A prospective observational study recruited 129 women with unruptured tubal pregnancy in the First Affiliated Hospital of Xi'an Jiaotong University from September 2016 to June 2018. One hundred and fifteen women were treated successfully with MTX, and women were divided into 2 groups according to luteal blood flow: the poor luteal blood flow group and the abundant luteal blood flow group. The therapeutic effects were compared between the two groups.

RESULTS

Women in the abundant luteal blood flow group had a significantly higher serum β-human chorionic gonadotropin (β-hCG) level 4 days, 1 week and 2 weeks after MTX treatment compared with women in the poor luteal blood flow group (P < 0.05). The average diameter of the ectopic mass 1 week, 2 weeks and 3 weeks after MTX treatment in women with abundant luteal blood flow was significantly larger (P < 0.05), and the time of serum β-hCG clearance and ectopic mass disappearance were significantly longer compared with those in women in the poor luteal blood flow group (P < 0.05).

CONCLUSIONS

Luteal blood flow might be a predictive factor for MTX treatment outcomes in women with unruptured tubal pregnancy, and those with abundant luteal blood flow need a longer recovery time.

摘要

背景

黄体中的血流与黄体功能有关。然而，黄体血流对未破裂输卵管妊娠妇女甲氨蝶呤（MTX）治疗的影响尚未报道。本研究旨在观察黄体血流对未破裂输卵管妊娠妇女 MTX 治疗效果的影响。

方法

一项前瞻性观察研究于 2016 年 9 月至 2018 年 6 月在西安交通大学第一附属医院招募了 129 例未破裂输卵管妊娠患者。115 例患者成功接受 MTX 治疗，根据黄体血流将患者分为两组：黄体血流不良组和黄体血流丰富组。比较两组的治疗效果。

结果

MTX 治疗后 4 天、1 周和 2 周，黄体血流丰富组患者血清β-人绒毛膜促性腺激素（β-hCG）水平明显高于黄体血流不良组（P<0.05）。MTX 治疗后 1 周、2 周和 3 周，黄体血流丰富组患者异位肿块的平均直径明显更大（P<0.05），血清β-hCG 清除时间和异位肿块消失时间明显长于黄体血流不良组（P<0.05）。

结论

黄体血流可能是预测未破裂输卵管妊娠妇女 MTX 治疗结局的一个因素，黄体血流丰富的患者需要更长的恢复时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/233b/7106736/ad8508df2c11/12884_2020_2882_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/233b/7106736/de21ff8e7076/12884_2020_2882_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/233b/7106736/c6adf3ad8305/12884_2020_2882_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/233b/7106736/97adf158e25f/12884_2020_2882_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/233b/7106736/ad8508df2c11/12884_2020_2882_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/233b/7106736/de21ff8e7076/12884_2020_2882_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/233b/7106736/c6adf3ad8305/12884_2020_2882_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/233b/7106736/97adf158e25f/12884_2020_2882_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/233b/7106736/ad8508df2c11/12884_2020_2882_Fig4_HTML.jpg

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本文引用的文献

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