用于智能药物释放的双刺激响应性纤维素纳米晶增强电纺聚（3-羟基丁酸酯-co-3-羟基戊酸酯）复合材料膜
Double stimuli-responsive cellulose nanocrystals reinforced electrospun PHBV composites membrane for intelligent drug release.
作者信息
Chen Yuxiang, Abdalkarim Somia Yassin Hussain, Yu Hou-Yong, Li Yingzhan, Xu Jiaxin, Marek Jaromir, Yao Juming, Tam Kam Chiu
机构信息
Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Ministry of Education, Zhejiang Provincial Key Laboratory of Fiber Materials and Manufacturing Technology, Zhejiang Sci-Tech University, Xiasha Higher Education Park Avenue 2 No.928, Hangzhou 310018, China.
Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Ministry of Education, Zhejiang Provincial Key Laboratory of Fiber Materials and Manufacturing Technology, Zhejiang Sci-Tech University, Xiasha Higher Education Park Avenue 2 No.928, Hangzhou 310018, China; Zhejiang Institute of Technology and Automatic Control, College of Mechanical and Automatic Control, Zhejiang Sci-Tech University, Hangzhou 310018, China.
出版信息
Int J Biol Macromol. 2020 Jul 15;155:330-339. doi: 10.1016/j.ijbiomac.2020.03.216. Epub 2020 Mar 27.
Double stimuli-responsive functionalized cellulose nanocrystal-poly[2-(dimethylamino)ethyl methacrylate] (CNC-g-PDMAEMA) reinforced poly(3-hydroxybutyrate-co-3-hydroxy valerate) (PHBV) electrospun composite membranes were explored as drug delivery vehicles using tetracycline hydrochloride (TH) as a model drug. It was found that rigid CNC-g-PDMAEMA nanoparticles enhanced thermal, crystallization and hydrophilic properties of PHBV. Moreover, great improvements in fiber diameter uniformity, crystallization ability and maximum decomposition temperature (T) could be achieved at 6 wt% CNC-g-PDMAEMA. Furthermore, by introducing stimuli-responsive CNC-g-PDMAEMA nanofillers, intelligent and long-term sustained release behavior of composite membranes could be achieved. The releasing mechanism of composite membranes based on zero order, first order, Higuchi and Korsmeyere-Peppas mathematical models was clearly demonstrated, giving effective technical guidance for practical drug delivery systems.
以盐酸四环素（TH）为模型药物，探索了双刺激响应功能化纤维素纳米晶-聚[2-（二甲氨基）乙基甲基丙烯酸酯]（CNC-g-PDMAEMA）增强聚（3-羟基丁酸酯-co-3-羟基戊酸酯）（PHBV）电纺复合膜作为药物递送载体。结果发现，刚性的CNC-g-PDMAEMA纳米颗粒增强了PHBV的热性能、结晶性能和亲水性能。此外，在CNC-g-PDMAEMA含量为6 wt%时，纤维直径均匀性、结晶能力和最大分解温度（T）有显著提高。此外，通过引入刺激响应性CNC-g-PDMAEMA纳米填料，复合膜可实现智能和长期的缓释行为。基于零级、一级、Higuchi和Korsmeyere-Peppas数学模型清晰地证明了复合膜的释放机制，为实际药物递送系统提供了有效的技术指导。
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