Liu Yubo, Chen Xiaohong, Liu Yuyang, Gao Yuhang, Liu Ping
School of Materials and Chemistry, University of Shanghai for Science & Technology, Shanghai 200093, China.
Shanghai Engineering Technology Research Center for High-Performance Medical Device Materials, Shanghai 200093, China.
Polymers (Basel). 2022 Jan 24;14(3):469. doi: 10.3390/polym14030469.
In a drug delivery system, the physicochemical properties of the polymeric matrix have a positive impact on the bioavailability of poorly water-soluble drugs. In this work, monolithic F1 fibers and coaxial F2 fibers were successfully prepared using polyvinylpyrrolidone as the main polymer matrix for drug loading and the poorly water-soluble curcumin (Cur) as a model drug. The hydrophobic poly (3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV) was designed as a blank layer to change the hydrophilicity of the fiber and restrain the drug dissolution rate. The curved linear morphology without beads of F1 fibers and the straight linear morphology with few spindles of F2 fibers were characterized using field-emission environmental scanning electron microscopy. The amorphous forms of the drug and its good compatibility with polymeric matrix were verified by X-ray diffraction and attenuated total reflectance Fourier transformed infrared spectroscopy. Surface wettability and drug dissolution data showed that the weaker hydrophilicity F2 fibers (31.42° ± 3.07°) had 24 h for Cur dissolution, which was much longer than the better hydrophilic F1 fibers (15.31° ± 2.79°) that dissolved the drug in 4 h.
在药物递送系统中，聚合物基质的物理化学性质对难溶性药物的生物利用度有积极影响。在本研究中，以聚乙烯吡咯烷酮作为主要聚合物基质用于载药，并以难溶性姜黄素（Cur）作为模型药物，成功制备了整体式F1纤维和同轴F2纤维。将疏水性聚（3-羟基丁酸-co-3-羟基戊酸）（PHBV）设计为空白层，以改变纤维的亲水性并抑制药物溶解速率。使用场发射环境扫描电子显微镜对无珠的F1纤维的曲线线性形态和有少量纺锤体的F2纤维的直线线性形态进行了表征。通过X射线衍射和衰减全反射傅里叶变换红外光谱验证了药物的无定形形式及其与聚合物基质的良好相容性。表面润湿性和药物溶解数据表明，亲水性较弱的F2纤维（31.42°±3.07°）使Cur溶解的时间为24小时，这比亲水性较好的F1纤维（15.31°±2.79°）将药物溶解所需的4小时长得多。
