News Feature: Avoiding pitfalls in the pursuit of a COVID-19 vaccine.
作者信息
Peeples Lynne
出版信息
Proc Natl Acad Sci U S A. 2020 Apr 14;117(15):8218-8221. doi: 10.1073/pnas.2005456117. Epub 2020 Mar 30.
Abstract
摘要
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Brief History and Characterization of Enhanced Respiratory Syncytial Virus Disease.呼吸道合胞病毒增强疾病的简史与特征
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A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge.一种双灭活严重急性呼吸综合征冠状病毒疫苗在小鼠中提供不完全保护，并在挑战时诱导嗜酸性炎症性肺部反应增加。
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Antibody-dependent enhancement of virus infection and disease.抗体依赖的病毒感染和疾病增强作用。
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Immune enhancement of viral infection.病毒感染的免疫增强
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Early death after feline infectious peritonitis virus challenge due to recombinant vaccinia virus immunization.重组痘苗病毒免疫后，猫感染性腹膜炎病毒攻击导致的早期死亡。
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