Department of Clinical and Translational Research Methodology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Food Research Institute of National Agriculture and Food Research Organization, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan.
Nutrients. 2020 Mar 27;12(4):915. doi: 10.3390/nu12040915.
The natto containing high levels of gamma-polyglutamic acid (γ-PGA) was recently developed. We investigated the effect of γ-PGA-rich natto consumption on postprandial glycemic excursion in humans. A randomized crossover meal test study was performed on healthy volunteers aged 20-64 years using the following test meals: (1) white rice (WR), (2) low-γ-PGA natto meal (WR + low-γ-PGA natto), and (3) high-γ-PGA natto meal (WR + high-γ-PGA natto). Blood samples were obtained at each visit before and for 120 min after loading. The incremental area under the curve (IAUC) of blood glucose and insulin levels was calculated and compared among the test meals. The blood glucose's IAUC at 0-120 min, the primary endpoint, was 20.1% and 15.4% lower for the high- and low-γ-PGA natto meal than for the WR, with a significant difference only between the high-γ-PGA natto meal and WR ( < 0.05). The blood glucose's IAUC at 0-15, 0-30, and 0-45 min was lower for the high-γ-PGA natto meal than for the low-γ-PGA natto meal (all < 0.05). The possibility that high-γ-PGA natto might suppress blood glucose elevations in the early phase after eating is indicated.
高 γ-聚谷氨酸（γ-PGA）纳豆最近被开发出来。我们研究了富含 γ-PGA 的纳豆消费对人体餐后血糖波动的影响。在 20-64 岁的健康志愿者中进行了一项随机交叉膳食测试研究，使用以下测试餐：（1）白米饭（WR），（2）低 γ-PGA 纳豆餐（WR+低 γ-PGA 纳豆），和（3）高 γ-PGA 纳豆餐（WR+高 γ-PGA 纳豆）。在每次就诊时，在负荷前和负荷后 120 分钟采集血样。计算并比较了测试餐之间血糖和胰岛素水平的增量曲线下面积（IAUC）。作为主要终点，高 γ-PGA 和低 γ-PGA 纳豆餐的血糖 0-120 分钟 IAUC 分别比 WR 低 20.1%和 15.4%，仅在高 γ-PGA 纳豆餐和 WR 之间存在显著差异（<0.05）。高 γ-PGA 纳豆餐的血糖 0-15、0-30 和 0-45 分钟 IAUC 均低于低 γ-PGA 纳豆餐（均<0.05）。高 γ-PGA 纳豆可能会抑制进食后早期血糖升高的可能性。
