LAQV, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Portugal, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
Mar Drugs. 2019 Nov 21;17(12):654. doi: 10.3390/md17120654.
The use of marine-origin polysaccharides has increased in recent research because they are abundant, cheap, biocompatible, and biodegradable. These features motivate their application in nanotechnology as drug delivery systems; in tissue engineering, cancer therapy, or wound dressing; in biosensors; and even water treatment. Given the physicochemical and bioactive properties of fucoidan and chitosan, a wide range of nanostructures has been developed with these polysaccharides per se and in combination. This review provides an outline of these marine polysaccharides, including their sources, chemical structure, biological properties, and nanomedicine applications; their combination as nanoparticles with descriptions of the most commonly used production methods; and their physicochemical and biological properties applied to the design of nanoparticles to deliver several classes of compounds. A final section gives a brief overview of some biomedical applications of fucoidan and chitosan for tissue engineering and wound healing.
近年来，由于海洋来源多糖具有丰富、廉价、生物相容和可生物降解等特点，其在科研中的应用日益增多。这些特性促使它们在纳米技术中作为药物传递系统；在组织工程、癌症治疗或伤口敷料；在生物传感器中；甚至在水处理中得到应用。鉴于褐藻糖胶和壳聚糖的物理化学和生物活性特性，已经用这些多糖本身和它们的组合开发了广泛的纳米结构。本文综述了这些海洋多糖，包括它们的来源、化学结构、生物特性和纳米医学应用；它们与纳米粒子结合的描述，以及最常用的生产方法；以及它们的物理化学和生物学特性在设计用于传递几类化合物的纳米粒子中的应用。最后一节简要概述了褐藻糖胶和壳聚糖在组织工程和伤口愈合方面的一些生物医学应用。
