Department of Food Hygiene and Environmental Health, University of Helsinki, Mustialankatu 1, FI-00790 Helsinki, Finland.
School of Pharmacy (Toxicology) and Department of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
Int J Mol Sci. 2020 Mar 28;21(7):2342. doi: 10.3390/ijms21072342.
Dioxins and related compounds are common environmental contaminants. Although their levels have gone down, they are still of concern, in particular regarding developmental toxicity. The adverse effects of these compounds are mediated by the aryl hydrocarbon receptor (AHR), whose canonical signaling pathway has been unveiled in fair detail. The alternative (non-genomic) pathways are much more obscure. AHR has also proven to be a master regulator of numerous physiological phenomena, which has led to the search of selective AHR modulators with low toxicity. Papers of this Special Issue address the developmental toxicity of dioxins and related compounds as well as selective modulators of AHR and both its canonical and alternative signaling pathways. In addition, new optical and stereoscopic methods for the detection of dioxins are presented. As a whole, this Special Issue provides an up-to-date view on a wide variety of aspects related to dioxin toxicity mechanisms from both original research articles and reviews.
二恶英和相关化合物是常见的环境污染物。尽管它们的水平已经下降，但仍令人关注，特别是在发育毒性方面。这些化合物的不良影响是由芳香烃受体（AHR）介导的，其经典信号通路已经得到了相当详细的揭示。替代（非基因组）途径则更加模糊。AHR 也被证明是许多生理现象的主要调节剂，这导致了对具有低毒性的选择性 AHR 调节剂的研究。本期特刊中的论文探讨了二恶英和相关化合物的发育毒性，以及 AHR 的选择性调节剂及其经典和替代信号通路。此外，还介绍了用于检测二恶英的新的光学和立体方法。总的来说，本期特刊从原创研究文章和综述两个方面提供了有关二恶英毒性机制的广泛而多样化的最新观点。
