Kolupaev G P, Iakovleva V A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(11):104-6.
Clinical and hormonal indices of androgenic activity were compared in 118 males chronically intoxicated with alcohol. The population was divided into two groups with respect to their clinical and hormonal androgenic indices: 76 patients with (Group 1), and 46 patients without (Group 2) androgenic insufficiency. Distinct signs and syndromes of alcohol addiction were shown to correlate with the extent of cross-regulation impairment within hypothalamo-hypophyseo-gonadal system. This was particularly derived from comparison of clinical picture of chronic alcohol intoxication and hormone activity in the groups. Conventional therapy failed to restore the neuroendocrine indices that was apparently due to inhibition of cross-regulation links in the hypothalamo-hypophyseo-gonadal system at several stages of alcohol addiction.
对118名长期酒精中毒男性的雄激素活性临床和激素指标进行了比较。根据临床和激素雄激素指标，将研究对象分为两组：76例有雄激素不足的患者（第1组）和46例无雄激素不足的患者（第2组）。结果显示，酒精成瘾的明显体征和综合征与下丘脑 - 垂体 - 性腺系统内交叉调节受损程度相关。这尤其源于两组慢性酒精中毒临床表现与激素活性的比较。常规治疗未能恢复神经内分泌指标，这显然是由于在酒精成瘾的几个阶段下丘脑 - 垂体 - 性腺系统的交叉调节联系受到抑制。
